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A diagnosis of Guillain Barr\u00e9 syndrome was made on the basis of clinical symptoms, cerebrospinal fluid analysis, and electroneurography. In all of them, the therapeutic approach included the administration of intravenous immunoglobulin (0.4\u2009gr\/kg for 5 days), which resulted in the improvement of neurological symptoms. Clinical neurophysiology revealed the presence of conduction block, absence of F waves, and in two cases, a significant decrease in amplitude of compound motor action potential cMAP. Due to the potential role of inflammation on symptoms development and prognosis, interleukin\u20106 (IL\u20106) and IL\u22128 levels were measured in serum and cerebrospinal fluid during the acute phase, while only serum was tested after recovery. Both IL\u20106 and IL\u20108 were found increased during the acute phase, both in the serum and cerebrospinal fluid, whereas 4 months after admission (at complete recovery), only IL\u20108 remained elevated in the serum. These results confirm the inflammatory response that might be linked to peripheral nervous system complications and encourage the use of IL\u20106 and IL\u20108 as prognostic biomarkers in COVID\u201019.<\/jats:p>","DOI":"10.1002\/jmv.27061","type":"journal-article","created":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T09:55:02Z","timestamp":1620294902000},"page":"5432-5437","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Cerebrospinal fluid and serum interleukins 6 and 8 during the acute and recovery phase in COVID\u201019 neuropathy patients"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5305-6268","authenticated-orcid":false,"given":"Paolo","family":"Manganotti","sequence":"first","affiliation":[{"name":"Clinical Unit of Neurology, Department of Medicine, Surgery and Health Sciences Cattinara University Hospital ASUGI, University of Trieste  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Bellavita","sequence":"additional","affiliation":[{"name":"Clinical Unit of Neurology, Department of Medicine, Surgery and Health Sciences Cattinara University Hospital ASUGI, University of Trieste  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Tommasini","sequence":"additional","affiliation":[{"name":"Clinical Unit of Neurology, Department of Medicine, Surgery and Health Sciences Cattinara University Hospital ASUGI, University of Trieste  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"D\u2032Acunto","sequence":"additional","affiliation":[{"name":"Clinical Unit of Neurology, Department of Medicine, Surgery and Health Sciences Cattinara University Hospital ASUGI, University of Trieste  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Fabris","sequence":"additional","affiliation":[{"name":"Lab. 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