{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:55:40Z","timestamp":1791824140324,"version":"4.3.4"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T00:00:00Z","timestamp":1622592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Cycloviruses (CyV) (genus Cyclovirus, family <jats:italic>Circoviridae<\/jats:italic>) are nonenveloped DNA viruses. The first report in humans was in 2010 and research has focused only on disease\u2010associated human sample detection. The only HuACyV (CyCV\u2010ChileNPA1, HuACyV10) reported in the Chilean population was in children (3.3%) with an acute respiratory infection. Its detection in respiratory samples from adults, with\/without respiratory disease remains unknown. The aim of this study was to detect HuACyV10 in adults with and without respiratory disease. HuACyV10 was studied in nasopharyngeal swabs from 105 hospitalized adults with community\u2010acquired pneumonia (CAP) and 104 adults without respiratory symptoms. Total nucleic acids were extracted, and viral <jats:italic>rep<\/jats:italic> and <jats:italic>cp<\/jats:italic> gene fragments were amplified by real\u2010time polymerase chain reaction. HuACyV10 was detected in 19.05% adults with CAP and in 0.96% asymptomatic adults, being significantly higher in adult CAP than asymptomatic (<jats:italic>n<\/jats:italic>\u2009=\u20091) ones (<jats:italic>p<\/jats:italic>\u2009=\u20090.0001). <jats:italic>C<\/jats:italic>\n<jats:sub>t<\/jats:sub> values were between 26.7 and 39.6, and the median was 34.1 for rep and 33.8 for the CAP in adults CAP (<jats:italic>p<\/jats:italic>\u2009=\u20090.68), and 35.7 and 36.0, respectively, in the asymptomatic case. HuACyV10 detection in CAP adults concentrated in the Autumn\u2013Winter season of the Southern hemisphere. The only asymptomatic adult with HuACyV10 was detected in the Spring\u2013Summer period. In this first report of HuACyV10 in respiratory samples from adults, detection was significantly higher in CAP than in asymptomatic adults. As the sensitivity of both <jats:italic>rep<\/jats:italic> and <jats:italic>cp<\/jats:italic> genes was similar, both can be applied for detecting HuACyV10. It would be advisable to investigate the pathogenic role of HuACyV10 in adult respiratory infections.<\/jats:p><jats:p>\u200b<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.27080","type":"journal-article","created":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T08:25:45Z","timestamp":1622795145000},"page":"4786-4793","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Cyclovirus detection in Chilean adults with and without community\u2010acquired pneumonia"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7553-9324","authenticated-orcid":false,"given":"Yara","family":"Prades","sequence":"first","affiliation":[{"name":"Programa de Virolog\u00eda, ICBM, Facultad de Medicina Universidad de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolando","family":"Pizarro","sequence":"additional","affiliation":[{"name":"Servicio Cl\u00ednico Hospital de Enfermedades Infecciosas Dr. L. C\u00f3rdova  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Norte Hospital Cl\u00ednico Universidad de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"Moreno","sequence":"additional","affiliation":[{"name":"Programa de Virolog\u00eda, ICBM, Facultad de Medicina Universidad de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis F.","family":"Avenda\u00f1o","sequence":"additional","affiliation":[{"name":"Programa de Virolog\u00eda, ICBM, Facultad de Medicina Universidad de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8008-5806","authenticated-orcid":false,"given":"Vivian","family":"Luchsinger","sequence":"additional","affiliation":[{"name":"Programa de Virolog\u00eda, ICBM, Facultad de Medicina Universidad de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02109-09"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-017-3247-y"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11262-015-1217-6"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2107.150228"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0118070"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.034108-0"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.000199"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.028704-0"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep07552"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00231-13"},{"key":"e_1_2_9_12_1","first-page":"98","volume-title":"Virology","author":"Phan TG","year":"2015"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2016.05.011"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.061143-0"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.030338-0"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.052654-0"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-013-1606-x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00145-18"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2015.05.007"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2019.07.007"},{"key":"e_1_2_9_21_1","first-page":"1","volume-title":"Ser. 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