{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T23:27:53Z","timestamp":1784590073920,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T00:00:00Z","timestamp":1622419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>The aim of our study was to evaluate the diagnostic performance of two antigen rapid diagnostic tests (Ag\u2010RDTs) to diagnose severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) infection. We evaluated <jats:italic>Panbio<\/jats:italic> and <jats:italic>SD\u2010Biosensor<\/jats:italic> Ag\u2010RDTs. We employed 186 polymerase chain reaction (PCR) negative samples to evaluate the specificity and 170 PCR positive samples to assess the sensitivity. We evaluated their sensitivity according to Cycle threshold (<jats:italic>C<\/jats:italic>\n<jats:sub>t<\/jats:sub>) values and days post onset of symptoms (d.p.o.). Tests were compared using the McNemar's test. Agreement was evaluated using the <jats:italic>kappa<\/jats:italic> score. Specificity was 100% for <jats:italic>Panbio<\/jats:italic> and 97.3% for <jats:italic>SD\u2010Biosensor<\/jats:italic>. Sensitivity for samples with <jats:italic>C<\/jats:italic>\n<jats:sub>t\u2009<\/jats:sub>\u2264\u200920 was 100% for both assays and for samples with <jats:italic>C<\/jats:italic>\n<jats:sub>t<\/jats:sub>\u2009=\u200920\u201325 was 93.0% (<jats:italic>Panbio<\/jats:italic>) and 95.3% (<jats:italic>SD\u2010Biosensor<\/jats:italic>) (<jats:italic>p<\/jats:italic>\u2009=\u2009\u20091.000). Sensitivity decreased for samples wit <jats:italic>C<\/jats:italic>\n<jats:sub>t<\/jats:sub>\u2009=\u200925\u201330 (<jats:italic>Panbio<\/jats:italic>: 41.3%, <jats:italic>SD\u2010Biosensor<\/jats:italic>: 52.2%, <jats:italic>p<\/jats:italic>\u2009=\u20090.125) and samples with <jats:italic>C<\/jats:italic>\n<jats:sub>t\u2009<\/jats:sub>\u2265\u200930 (<jats:italic>Panbio<\/jats:italic>: 5.0%, <jats:italic>SD\u2010Biosensor<\/jats:italic>: 17.5%, <jats:italic>p<\/jats:italic>\u2009=\u20090.063). Sensitivity within seven d.p.o. was 87.7% for Panbio and 90.4% for SD\u2010Biosensor and notably decreased after seven d.p.o. Agreement with PCR was excellent for high viral load samples (<jats:italic>C<\/jats:italic>\n<jats:sub>t<\/jats:sub>\u2009\u2264\u200925): <jats:italic>Panbio<\/jats:italic>, 98.9%, <jats:italic>kappa<\/jats:italic>\u2009=\u20090.974; <jats:italic>SD\u2010Biosensor<\/jats:italic>, 97.4%, <jats:italic>kappa<\/jats:italic>\u2009=\u20090.940. Agreement between Ag\u2010RDTs was excellent (94.9%, <jats:italic>kappa<\/jats:italic>\u2009=\u20090.882).\u00a0<jats:italic>Panbio<\/jats:italic> and <jats:italic>SD\u2010Biosensor<\/jats:italic> Ag\u2010RDTs showed excellent agreement and diagnostic performance results for samples with high viral loads (<jats:italic>C<\/jats:italic>\n<jats:sub>t\u2009<\/jats:sub>\u2264\u200925) or samples within seven d.p.o.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.27089","type":"journal-article","created":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T06:54:34Z","timestamp":1621320874000},"page":"5650-5654","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Comparative evaluation of Panbio and SD Biosensor antigen rapid diagnostic tests for COVID\u201019 diagnosis"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4885-4334","authenticated-orcid":false,"given":"Felipe","family":"P\u00e9rez\u2010Garc\u00eda","sequence":"first","affiliation":[{"name":"Servicio de Microbiolog\u00eda Cl\u00ednica Hospital Universitario Pr\u00edncipe de Asturias  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Romanyk","sequence":"additional","affiliation":[{"name":"Servicio de Microbiolog\u00eda Cl\u00ednica Hospital Universitario Pr\u00edncipe de Asturias  Madrid Spain"},{"name":"Departamento de Biomedicina y Biotecnolog\u00eda, Facultad de Medicina Universidad de Alcal\u00e1 de Henares  Alcal\u00e1 de Henares Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Moya Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Servicio de Microbiolog\u00eda Cl\u00ednica Hospital Universitario Pr\u00edncipe de Asturias  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Labrador Ballestero","sequence":"additional","affiliation":[{"name":"Servicio de Microbiolog\u00eda Cl\u00ednica Hospital Universitario Pr\u00edncipe de Asturias  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00e9s","family":"P\u00e9rez Ranz","sequence":"additional","affiliation":[{"name":"Servicio de Microbiolog\u00eda Cl\u00ednica Hospital Universitario Pr\u00edncipe de Asturias  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Gonz\u00e1lez Arroyo","sequence":"additional","affiliation":[{"name":"Servicio de Microbiolog\u00eda Cl\u00ednica Hospital Universitario Pr\u00edncipe de Asturias  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Gonz\u00e1lez Ventosa","sequence":"additional","affiliation":[{"name":"Servicio de Microbiolog\u00eda Cl\u00ednica Hospital Universitario Pr\u00edncipe de Asturias  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9816-3208","authenticated-orcid":false,"given":"Ram\u00f3n","family":"P\u00e9rez\u2010Tanoira","sequence":"additional","affiliation":[{"name":"Servicio de Microbiolog\u00eda Cl\u00ednica Hospital Universitario Pr\u00edncipe de Asturias  Madrid Spain"},{"name":"Departamento de Biomedicina y Biotecnolog\u00eda, Facultad de Medicina Universidad de Alcal\u00e1 de Henares  Alcal\u00e1 de Henares Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concepci\u00f3n","family":"Domingo Cruz","sequence":"additional","affiliation":[{"name":"Servicio de Microbiolog\u00eda Cl\u00ednica Hospital Universitario Pr\u00edncipe de Asturias  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Cuadros\u2010Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Servicio de Microbiolog\u00eda Cl\u00ednica Hospital Universitario Pr\u00edncipe de Asturias  Madrid Spain"},{"name":"Departamento de Biomedicina y Biotecnolog\u00eda, Facultad de Medicina Universidad de Alcal\u00e1 de Henares  Alcal\u00e1 de Henares Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,31]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics10040202"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-020-00461-z"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp2025631"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1101\/2020.06.22.20136309"},{"key":"e_1_2_9_6_1","unstructured":"World Health Organization. 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COMMISSION RECOMMENDATION of 18.11.2020 on the use of rapid antigen tests for the diagnosis of SARS\u2010CoV\u20102 infection;2020.https:\/\/ec.europa.eu\/health\/sites\/health\/files\/preparedness_response\/docs\/sarscov2_rapidantigentests_recommendation_en.pdf"},{"key":"e_1_2_9_20_1","unstructured":"European Centre for Disease Prevention and Control. Options for the use of rapid antigen tests for COVID\u201019 in the EU\/EEA and the UK. TECHNICAL REPORT;2020.https:\/\/www.ecdc.europa.eu\/en\/publications-data\/options-use-rapid-antigen-tests-covid-19-eueea-and-uk. 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