{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:13:26Z","timestamp":1772118806008,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T00:00:00Z","timestamp":1623110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>In the current coronavirus disease 2019 (COVID\u201019) pandemic there is a mass screening of severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) happening around the world due to the extensive spread of the infections. There is a high demand for rapid diagnostic tests to expedite the identification of cases and to facilitate early isolation and control spread. Hence this study evaluates six different rapid nucleic acid detection assays that are commercially available for SARS\u2010CoV\u20102 virus detection. Nasopharyngeal samples were collected from 4981 participants and were tested for the SARS\u2010CoV\u20102 virus by the gold standard real\u2010time reverse\u2010transcription polymerase chain reaction (RT\u2010PCR) method and with one of these six rapid methods of detection. Evaluation of the rapid nucleic acid detection assays was done by comparing the results of these rapid methods with the gold standard RT\u2010qPCR results for SARS\u2010COV\u20102 detection. AQ\u2010TOP had the highest sensitivity (98%) and a strong kappa value of 0.943 followed by Genechecker and Abbot ID NOW. The POCKIT (ii RT\u2010PCR) assay had the highest test accuracy of 99.29% followed by Genechecker and Cobas Liat. Atila iAMP showed the highest percentage of invalid reports (35.5%) followed by AQ\u2010TOP with 6% and POCKIT with 3.7% of invalid reports. Genechecker system, Abbott ID NOW, and Cobas Liat were found to have the best performance and agreement when compared with the standard RT\u2010PCR for COVID\u201019 detection. With further research, these rapid tests have the potential to be employed in large\u2010scale screening of COVID\u201019.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmv.27090","type":"journal-article","created":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T02:56:09Z","timestamp":1621306569000},"page":"5538-5543","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Evaluation of six different rapid methods for nucleic acid detection of SARS\u2010COV\u20102 virus"],"prefix":"10.1002","volume":"93","author":[{"given":"Sally A.","family":"Mahmoud","sequence":"first","affiliation":[{"name":"Biogenix Lab G42  Abu Dhabi UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2860-3503","authenticated-orcid":false,"given":"Subhashini","family":"Ganesan","sequence":"additional","affiliation":[{"name":"G42 Healthcare  Abu Dhabi UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esra","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Biogenix Lab G42  Abu Dhabi UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhagyashree","family":"Thakre","sequence":"additional","affiliation":[{"name":"Biogenix Lab G42  Abu Dhabi UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliet G.","family":"Teddy","sequence":"additional","affiliation":[{"name":"Biogenix Lab G42  Abu Dhabi UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Preety","family":"Raheja","sequence":"additional","affiliation":[{"name":"Biogenix Lab G42  Abu Dhabi UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walid A.","family":"Zaher","sequence":"additional","affiliation":[{"name":"G42 Healthcare  Abu Dhabi UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6,8]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"Worldometers.2020.https:\/\/www.worldometers.info\/coronavirus\/country\/. 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