{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T04:54:41Z","timestamp":1780980881745,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,6,6]],"date-time":"2021-06-06T00:00:00Z","timestamp":1622937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870413"],"award-info":[{"award-number":["81870413"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study is to explore the relationship between liver pathological inflammation degree and pyroptosis in patients with chronic hepatitis B (CHB). One hundred and twenty CHB patients' liver tissue samples, including A0\u2013A3 inflammatory grades, were selected. Six tissue sections were selected for each indicator in each inflammation grade. The results of immunohistochemical analysis on the pyroptosis\u2010related molecules (NLRP3, GSDMD, caspase1, interleukin [IL]\u20101\u03b2, and IL\u201018) were determined. The correlation between the pyroptosis\u2010related molecules and liver inflammatory activities was analyzed. The expression of NLRP3, GSDMD, caspase1, IL\u201018, and IL\u20101\u03b2 was respectively significantly positively correlated with the grade of inflammatory activity (<jats:italic>r<\/jats:italic>\n<jats:sub>\n<jats:italic>s<\/jats:italic>\n<\/jats:sub>\u2009=\u20090.690, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01; <jats:italic>r<\/jats:italic>\n<jats:sub>\n<jats:italic>s<\/jats:italic>\n<\/jats:sub>\u2009=\u20090.681, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01; <jats:italic>r<\/jats:italic>\n<jats:sub>\n<jats:italic>s<\/jats:italic>\n<\/jats:sub>\u2009=\u20090.540, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01; <jats:italic>r<\/jats:italic>\n<jats:sub>\n<jats:italic>s<\/jats:italic>\n<\/jats:sub>\u2009=\u20090.725, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01; <jats:italic>r<\/jats:italic>\n<jats:sub>\n<jats:italic>s<\/jats:italic>\n<\/jats:sub>\u2009=\u20090.663, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) and linear relationship (<jats:italic>\u03c7<\/jats:italic>\n<jats:sup>2<\/jats:sup>\u2009=\u200956.763, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01; <jats:italic>\u03c7<\/jats:italic>\n<jats:sup>2<\/jats:sup>\u2009=\u200955.350, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01; <jats:italic>\u03c7<\/jats:italic>\n<jats:sup>2<\/jats:sup>\u2009=\u200934.776, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01; <jats:italic>\u03c7<\/jats:italic>\n<jats:sup>2<\/jats:sup>\u2009=\u200962.523, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01; <jats:italic>\u03c7<\/jats:italic>\n<jats:sup>2<\/jats:sup>\u2009=\u200952.521, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) in liver tissue. The high expression of NLRP3, GSDMD, caspase1, IL\u20101\u03b2, and IL\u201018 may be involved in the process of liver tissue inflammation and damage, which is positively correlated with liver tissue inflammation in patients with CHB.<\/jats:p>","DOI":"10.1002\/jmv.27114","type":"journal-article","created":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T15:52:41Z","timestamp":1622562761000},"page":"6229-6235","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The relationship between liver pathological inflammation degree and pyroptosis in chronic hepatitis B patients"],"prefix":"10.1002","volume":"93","author":[{"given":"Yao","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Renmin Hospital of Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Renmin Hospital of Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Renmin Hospital of Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangzhou","family":"Jiao","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Renmin Hospital of Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxia","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Renmin Hospital of Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maohua","family":"Pei,","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Renmin Hospital of Wuhan University  Wuhan 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