{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T06:13:52Z","timestamp":1768284832267,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,6,10]],"date-time":"2021-06-10T00:00:00Z","timestamp":1623283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009054","name":"International Centre for Diarrhoeal Disease Research, Bangladesh","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Human sapovirus, which causes acute gastroenteritis, is not well studied and poorly understood. This study aims to investigate the contribution of sapovirus in diarrhea, their clinical association, and genotypic diversity. Fecal specimens (<jats:italic>n<\/jats:italic>\u2009=\u2009871) were randomly selected from diarrheal patients who attended International Centre for Diarrhoeal Disease Research, Bangladesh hospital in Dhaka, Bangladesh during January 2012\u2013December 2015 and tested for the presence of sapovirus RNA using real\u2010time polymerase chain reaction. Sapovirus RNA was identified in 2.3% (<jats:italic>n<\/jats:italic>\u2009=\u200920) of the samples. Seventy\u2010five percent of the sapovirus positive cases were coinfected with other pathogens, such as rotavirus, norovirus, enterotoxigenic\u00a0<jats:italic>Escherichia coli<\/jats:italic>, adenovirus, <jats:italic>Shigella spp<\/jats:italic>., and <jats:italic>Vibrio cholerae<\/jats:italic>. A vast genetic diversity was observed among sapovirus with at least seven common genotypes (GI.1, GI.2, GI.7, GII.1, GII.4, GII.6, and GIV), and a new genotype GII.NA1. Some of the GI.1 strains detected were similar to GI.4 in the polymerase region sequence and were confirmed as recombinant strains. Our findings suggest that the overall contribution of sapovirus in hospitalized diarrheal illness is low but highlight enormous genetic diversity.<\/jats:p>","DOI":"10.1002\/jmv.27125","type":"journal-article","created":{"date-parts":[[2021,6,3]],"date-time":"2021-06-03T20:07:16Z","timestamp":1622750836000},"page":"6220-6228","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Epidemiology and genetic characterization of human sapovirus among hospitalized acute diarrhea patients in Bangladesh, 2012\u20132015"],"prefix":"10.1002","volume":"93","author":[{"given":"Rajibur","family":"Rahman","sequence":"first","affiliation":[{"name":"Virology Laboratory, Infectious Diseases Division (IDD) International Centre for Diarrhoeal Disease Research (ICDDR), Bangladesh  Dhaka Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0092-9261","authenticated-orcid":false,"given":"Sezanur","family":"Rahman","sequence":"additional","affiliation":[{"name":"Virology Laboratory, Infectious Diseases Division (IDD) International Centre for Diarrhoeal Disease Research (ICDDR), Bangladesh  Dhaka Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md M. 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