{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T17:56:02Z","timestamp":1769104562433,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,6,12]],"date-time":"2021-06-12T00:00:00Z","timestamp":1623456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim was to investigate the association of the delivery mode and vertical transmission of severe acute respiratory syndrome coronavirus\u20102 (SARS\u2010CoV\u20102) through the samples of vaginal secretions, placenta, cord blood, or amniotic fluid as well as the neonatal outcomes. This cross\u2010sectional study presents an analysis of prospectively gathered data collected at a single tertiary hospital. Sixty\u2010three pregnant women with confirmed coronavirus disease 2019 (COVID\u201019) participated in the study. Vertical transmission of SARS\u2010CoV\u20102 was analyzed with reverse transcriptase\u2010polymerase chain reaction (RT\u2010PCR) tests and blood tests for immunoglobulin G (IgG)\u2013immunoglobulin M (IgM) antibodies. All patients were in the mild or moderate category for COVID\u201019. Only one placental sample and two of the vaginal secretion samples were positive for SARS\u2010CoV\u20102. Except for one, all positive samples were obtained from patients who gave birth by cesarean. All cord blood and amniotic fluid samples were negative for SARS\u2010CoV\u20102. Two newborns were screened positive for COVID\u201019 IgG\u2013IgM within 24\u2009h after delivery, but the RT\u2010PCR tests were negative. A positive RT\u2010PCR result was detected in a neof a mother whose placenta, cord blood, amniotic fluid, and vaginal secretions samples were negative. He died due to pulmonary hemorrhage on the 11th day of life. In conclusion, we demonstrated that SARS\u2010CoV\u20102 can be detectable in the placenta or vaginal secretions of pregnant women. Detection of the virus in the placenta or vaginal secretions may not be associated with neonatal infection. Vaginal delivery may not increase the incidence of neonatal infection, and cesarean may not prevent vertical transmission. The decision regarding the mode of delivery should be based on obstetric indications and COVID\u201019 severity.<\/jats:p>","DOI":"10.1002\/jmv.27128","type":"journal-article","created":{"date-parts":[[2021,6,3]],"date-time":"2021-06-03T20:18:19Z","timestamp":1622751499000},"page":"5864-5872","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Vertical transmission of SARS\u2010CoV\u20102: A prospective cross\u2010sectional study from a tertiary center"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3118-4036","authenticated-orcid":false,"given":"Selcan","family":"Sinaci","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Ministry of Health Ankara City Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4727-7982","authenticated-orcid":false,"given":"Doga 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