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Earlier studies across eastern India revealed a shift in the predominance of genotypes from HAdV41 in 2007\u201309 to HAdV40 in 2013\u201314. Thus, the surveillance for HAdV\u2010F genotypes in this geographical setting was undertaken over\u00a02017\u20132020 to analyze the viral evolutionary dynamics. A total of 3882 stool samples collected from children (\u22645 years) were screened for HAdV\u2010F positivity by conventional PCR. The hypervariable regions of the hexon and the partial shaft region of long fiber genes were amplified, sequenced, and phylogenetically analyzed with respect to the prototype strains. A marginal decrease in enteric HAdV prevalence was observed (9.04%, <jats:italic>n<\/jats:italic>\u2009=\u2009351\/3882) compared to the previous report (11.8%) in this endemic setting. Children &lt;2 years were found most vulnerable to enteric HAdV infection. Reduction in adenovirus\u2010rotavirus co\u2010infection was evident compared to the sole adenovirus infection. HAdV\u2010F genotypes 40 and 41 were found to co\u2010circulate, but HAdV41 was predominant. HAdV40 strains were genetically conserved, whereas HAdV41 strains accumulated new mutations. On the basis of a different set of mutations in their genome, HAdV41 strains segregated into 2 genome type clusters (GTCs). Circulating HAdV41 strains clustered with GTC1 of the fiber gene, for the first time during this study period. This study will provide much\u2010needed baseline data on the emergence and circulation of HAdV40\/41 strains for future vaccine development.<\/jats:p>","DOI":"10.1002\/jmv.27136","type":"journal-article","created":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T15:39:47Z","timestamp":1623944387000},"page":"6180-6190","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Genetic characterization and phylogenetic variations of human adenovirus\u2010F strains circulating in eastern India during 2017\u20132020"],"prefix":"10.1002","volume":"93","author":[{"given":"Pritam","family":"Chandra","sequence":"first","affiliation":[{"name":"Division of Virology National Institute of Cholera and Enteric Diseases, Beliaghata  Kolkata West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahadeb","family":"Lo","sequence":"additional","affiliation":[{"name":"Division of Virology National Institute of Cholera and Enteric Diseases, Beliaghata  Kolkata West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suvrotoa","family":"Mitra","sequence":"additional","affiliation":[{"name":"Division of Virology National Institute of Cholera and Enteric Diseases, Beliaghata  Kolkata West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anindita","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Division of Virology National Institute of Cholera and Enteric Diseases, Beliaghata  Kolkata West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Saha","sequence":"additional","affiliation":[{"name":"Division of Virology National Institute of Cholera and Enteric Diseases, Beliaghata  Kolkata West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keinosuke","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Collaborative Research Centre of Okayama University for Infectious Disease at Indian ICMR\u2010National Institute of Cholera and Enteric Diseases, Beliaghata  Kolkata West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alok Kumar","family":"Deb","sequence":"additional","affiliation":[{"name":"Division of Epidemiology ICMR\u2010National Institute of Cholera and Enteric Diseases, Beliaghata  Kolkata West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanat Kumar","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Dr. B.C. 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