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Human leukocyte antigen\u2010G (HLA\u2010G) is physiologically expressed during pregnancy, but decreased in normal placenta during the last weeks of gestation possibly inducing childbirth. Several viruses involved in congenital infection, such as herpesviruses, exploit HLA\u2010G expression as an immune\u2010escape mechanism. To date, despite different congenital herpetic infections having\u00a0been associated with late IUGR, no direct implication of Human herpesvirus 6 (HHV\u20106) infection has been reported. We evaluated HLA\u2010G expression and HHV\u20106 infection in 11 placentas from late\u2010onset IUGR newborns and 11 placentas from uncomplicated pregnancies by histopathological and immunohistochemistry analysis. We found higher levels of HLA\u2010G expression and HHV\u20106 presence in IUGR placenta samples compared with control placenta samples. We report HHV\u20106 staining in IUGR placenta samples, characterized by high HLA\u2010G expression. 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