{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T20:12:36Z","timestamp":1770754356793,"version":"3.50.0"},"reference-count":24,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T00:00:00Z","timestamp":1624406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81401306"],"award-info":[{"award-number":["81401306"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Interleukin\u201032 (IL\u201032), a multiple proinflammatory cytokine, plays\u00a0a vital role in immune\u2010related diseases and infectious diseases. The promoter region of IL\u201032, which showed functional polymorphism, could regulate IL\u201032 expression. Although IL\u201032 rs28372698 polymorphism has been\u00a0related to a lot of inflammatory diseases, the association of IL\u201032 rs28372698 polymorphism with a\u00a0hepatic flare of chronic HBV infection has\u00a0not been reported. In the present study, IL\u201032 rs28372698 polymorphism was genotyped in 104 chronic HBV carriers and 151 active chronic hepatitis B (CHB) patients. The frequency of IL\u201032 T\/T genotype in patients with active CHB was significantly higher than that in chronic HBV carriers. Furthermore, the frequency of the T allele at IL\u201032 rs28372698 in active CHB patients was also higher than that in chronic HBV carriers. The serum level of IL\u201032 in active CHB patients was higher than that in chronic HBV carriers. Our results imply that IL\u201032 T\/T polymorphism might be associated with a hepatic flare of chronic HBV infection.<\/jats:p>","DOI":"10.1002\/jmv.27140","type":"journal-article","created":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T15:42:40Z","timestamp":1623944560000},"page":"6236-6240","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association of IL\u201032 rs28372698 polymorphism with active chronic HBV infection"],"prefix":"10.1002","volume":"93","author":[{"given":"Shuo","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases The Third Affiliated Hospital of Guangzhou Medical University  Guangzhou China"},{"name":"Biomedicine Research Center The Third Affiliated Hospital of Guangzhou Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Li","sequence":"additional","affiliation":[{"name":"VIP 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