{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T17:25:28Z","timestamp":1769016328025,"version":"3.49.0"},"reference-count":15,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Rapid antigen detection (RAD) tests for the detection of SARS\u2010CoV\u20102 are simpler, faster, and less expensive than the reverse\u2010transcription polymerase chain reaction (RT\u2010PCR) that is currently considered the gold standard for the diagnosis of coronavirus disease 2019 (COVID\u201019). The objective of this study was to determine the performance of the PANBIO COVID\u201019 Ag RAD (Abbott) test, a lateral flow immunoassay that detects the nucleocapsid protein, using as a reference RT\u2010PCR method the Cobas\u00ae8800 System (Roche Diagnostics). This prospective study was conducted in a tertiary Children's Hospital and included individuals aged \u226416 years with COVID\u201019\u2010related symptoms or epidemiological criteria for COVID\u201019. Two nasopharyngeal samples were collected to perform the PANBIO RAD test and RT\u2010PCR. Of 744 children included, 51 (6.86%) had a positive RT\u2010PCR result. The RAD test detected 42 of 51 PCR\u2010positive children while there were no false\u2010positive results. The overall sensitivity and specificity were 82.35% (95% CI, 71.9%\u201392.8%) and 100%, respectively. Sensitivity was &gt;95% in symptomatic children. The assay performed poorly in asymptomatically infected children. In agreement with previous studies in adults, the PANBIO RAD test can be useful in screening for\u00a0COVID\u201019 in children admitted with symptoms suggestive of the disease, especially in the first days of the illness.<\/jats:p>","DOI":"10.1002\/jmv.27149","type":"journal-article","created":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T11:29:55Z","timestamp":1624361395000},"page":"6040-6044","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Real\u2010life evaluation of a COVID\u201019 rapid antigen detection test in hospitalized children"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5093-8502","authenticated-orcid":false,"given":"Irini","family":"Eleftheriou","sequence":"first","affiliation":[{"name":"Second Department of Pediatrics National and Kapodistrian University of Athens, \u201cP. and A. Kyriakou\u201d Children's Hospital Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Foteini","family":"Dasoula","sequence":"additional","affiliation":[{"name":"Second Department of Pediatrics National and Kapodistrian University of Athens, \u201cP. and A. Kyriakou\u201d Children's Hospital Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitra","family":"Dimopoulou","sequence":"additional","affiliation":[{"name":"Second Department of Pediatrics National and Kapodistrian University of Athens, \u201cP. and A. Kyriakou\u201d Children's Hospital Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evangelia","family":"Lebessi","sequence":"additional","affiliation":[{"name":"Department of Microbiology \u201cP. and A. Kyriakou\u201d Children's Hospital Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eftihia","family":"Serafi","sequence":"additional","affiliation":[{"name":"Ethniko Kentro Aimodosias (E.KE.A) Acharnes Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikos","family":"Spyridis","sequence":"additional","affiliation":[{"name":"Second Department of Pediatrics National and Kapodistrian University of Athens, \u201cP. and A. Kyriakou\u201d Children's Hospital Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Tsolia","sequence":"additional","affiliation":[{"name":"Second Department of Pediatrics National and Kapodistrian University of Athens, \u201cP. and A. 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