{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T01:51:57Z","timestamp":1792461117011,"version":"4.5.0"},"reference-count":68,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T00:00:00Z","timestamp":1625529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The role of human papillomavirus (HPV) in the development of oral lesions is controversial. There has been\u00a0no comprehensive study about HPV prevalence in Iran. This systematic review and meta\u2010analysis were aimed at\u00a0finding HPV prevalence of oral lesions and normal oral mucosa in Iran. International (PubMed, Web of Science, and Scopus) and national (Iranmedex, Irandoc, and SID) databases were searched systematically until October 2020. Studies that examined the prevalence of HPV in oral lesions by polymerase chain reaction method were included. The heterogeneity of articles was assessed with the Cochran test and I\u2010Square statistics. The prevalence rate of HPV was calculated using a random\u2010effect model. Of 3729 initially searched articles, 29 articles were eligible for\u00a0inclusion. The overall prevalence of HPV in oral lesions was 21%. The prevalence was the highest in Rasht (50%) city. Lip lesions had the highest HPV prevalence (40%). According to the classification of lesions, the highest prevalence was of\u00a0precancerous lesions (29%) and the lowest in normal mucosa (8%). Well\u2010differentiated tumors showed a higher prevalence than poorly\u2010differentiated ones. The highest prevalence of HPV was hairy leukoplakia (70%) and the lowest was of\u00a0pyogenic granuloma (6%). Also, the prevalence was 31% in oral squamous cell carcinoma. There are differences between HPV prevalence according to the geographical area, intraoral location, type of lesion, and grading. As\u00a0HPV prevalence was fairly\u00a0high, further attention to vaccination and treatment for HPV in Iran, as a potential risk factor for oral precancerous and cancerous lesions\u00a0is recommended.<\/jats:p>","DOI":"10.1002\/jmv.27161","type":"journal-article","created":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T07:16:57Z","timestamp":1624864617000},"page":"6089-6099","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Prevalence of human papillomavirus (HPV) in oral mucosal lesions in Iran: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"93","author":[{"given":"Farideh","family":"Aghaeipour","sequence":"first","affiliation":[{"name":"Student Research Committee Birjand University of Medical Sciences Birjand Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid","family":"Salehiniya","sequence":"additional","affiliation":[{"name":"Social Determinants of Health Research Center Birjand University of Medical Sciences Birjand Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7443-0607","authenticated-orcid":false,"given":"Hamid","family":"Abbaszadeh","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, Faculty of Dentistry Birjand University of Medical Sciences Birjand Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,6]]},"reference":[{"key":"e_1_2_8_2_1","article-title":"Human papillomavirus and head and neck squamous cell carcinoma in a UK population: Is there an association?","author":"Al\u2010Dabbagh R","year":"2021","journal-title":"Indian J Cancer"},{"issue":"1","key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.4103\/cmi.cmi_102_20","article-title":"Human papilloma virus testing in oral squamous cell carcinoma in Southern India: A case\u2010control 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