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We aimed to validate an algorithm (risk evaluation of viral load elevation and associated liver disease\/HCV [REVEAL\u2010HCV]: age, AST, ALT, HCV RNA, HCV genotype, and cirrhosis) developed in Taiwanese patients. We analyzed 1381 (50.1% White, 14.7% Hispanic, 13.8% Asian of diverse origin, and 7.8% African American) adult treatment\u2010na\u00efve HCV patients (no viral co\u2010infection, no HCC within 6 months) at 4 U.S. and one Hong Kong centers (11\/1994\u201310\/2017). Compared to the non\u2010Asian cohort, the Asian cohort had a higher percentage of patients in the low\u2010risk group (46.1% vs. 26.1%) and a lower percentage in the high\u2010risk group (12.0% vs. 20.3%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). Overall, 5\u2010year HCC incidence were 1.75%, 4.71%, and 24.4% for low, medium, and high\u2010risk patients, respectively (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). For the overall cohort, area under receiving operating characteristic curve (AUROC) for HCC prediction were 0.83 (95% confidence interval [CI]: 0.72\u20130.93), 0.82 (95% CI: 0.75\u20130.88), and 0.84 (95% CI: 0.77\u20130.89) for 1\u2010, 3\u2010, and 5\u2010year HCC risk, respectively. There was a slightly lower AUROC for Asians compared to the non\u2010Asian cohort at 3 years (0.75 vs. 0.83) and 5 years (0.78 vs. 0.84), though this was not statistically significant. In multivariable analysis, we found male sex, presence of metabolic syndrome as well as the risk score categories to be independently associated with HCC but not ethnicity. The REVEAL\u2010HCV risk score has good validity for both Asian and non\u2010Asian populations. Further studies should consider additional factors, such as sex, metabolic syndrome, and treatment status.<\/jats:p>","DOI":"10.1002\/jmv.27168","type":"journal-article","created":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T08:21:23Z","timestamp":1625473283000},"page":"6257-6266","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of ethnic influence in the application of a hepatocellular carcinoma predictive model for chronic hepatitis C"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4756-9010","authenticated-orcid":false,"given":"Mike T.","family":"Wei","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Stanford University  Palo Alto California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael H.","family":"Le","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Stanford University  Palo Alto California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Landis","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine University of Washington  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huy","family":"Trinh","sequence":"additional","affiliation":[{"name":"San Jose Gastroenterology  San Jose California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace","family":"Wong","sequence":"additional","affiliation":[{"name":"Institute of Digestive Disease The Chinese University of Hong Kong  Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"An","family":"Le","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Stanford University  Palo Alto California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Chinese Hospital  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramsey","family":"Cheung","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Stanford University  Palo Alto California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6275-4989","authenticated-orcid":false,"given":"Mindie H.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Stanford University  Palo Alto California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,7,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiz479"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30297"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.09.014"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2005.05.003"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMct061675"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.12.061"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27222"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24199"},{"key":"e_1_2_9_10_1","doi-asserted-by":"crossref","unstructured":"AASLD\/IDSA HCV Guidance Panel. 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