{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T01:24:16Z","timestamp":1788485056867,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T00:00:00Z","timestamp":1626134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Some previous studies suggested that the plasma exchange (PE) and hemoperfusion (HP) played a cardinal role in the treatment of severe coronavirus disease 2019 (COVID\u201019) cases by diminishing the cytokine storm. This study aimed to assess the effects of PE and HP on cytokine storms in patients with severe COVID\u201019 through a systematic scoping review. Four Electronic databases (Medline [accessed from PubMed], Scopus, Science Direct, and Cochrane library) were searched systematically on February 2, 2021, using MESH terms and related keywords in the English language. Considering the titles and abstracts, unrelated studies were excluded. The full texts of the remained studies were evaluated by authors, independently. Then, their findings were assessed and reported. A total of 755 articles were obtained within the first step of searching, and 518\u00a0remained after removing the duplications. Through the title and abstract screening, 438 were removed. Of the rest, 59 papers were excluded. Finally, after reading the full text of the remained articles, 21 were\u00a0included in data extraction. Most of the previously reported evidence were case reports and case series. Findings were summarized in two categories.\u00a0The first category encompassed nine studies regarding HP and continuous renal replacement therapy, and the second category included twelve studies about PE. The results revealed that HP and PE within the cytokine storm phase would be beneficial with a high probability in the treatment of severely ill COVID\u201019 patients.<\/jats:p><jats:p><jats:bold>Highlights<\/jats:bold> Some studies showed that plasma exchange (PE) and hemoperfusion (HP) played an important role in the treatment of patients with severe COVID\u201019 disease. The results of this systematic scoping review revealed that HP and PE within the cytokine storm phase would be beneficial with a high probability in the treatment of severely ill COVID\u201019 patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.27182","type":"journal-article","created":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T15:13:52Z","timestamp":1625584432000},"page":"5742-5755","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Investigation of plasma exchange and hemoperfusion effects and complications for the treatment of patients with severe COVID\u201019 (SARS\u2010CoV\u20102) disease: A systematic scoping review"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9483-8848","authenticated-orcid":false,"given":"Razieh Sadat","family":"Mousavi\u2010Roknabadi","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, School of Medicine Shiraz University of Medical Sciences Shiraz Iran"},{"name":"Emergency Medicine Research Center Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8894-5399","authenticated-orcid":false,"given":"Fatemeh","family":"Haddad","sequence":"additional","affiliation":[{"name":"Department of Medical Physiology Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2538-1973","authenticated-orcid":false,"given":"Aylar","family":"Fazlzadeh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6366-8575","authenticated-orcid":false,"given":"Dorna","family":"Kheirabadi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care, School of Medicine Isfahan University of Medical Sciences Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6772-7170","authenticated-orcid":false,"given":"Hamidreza","family":"Dehghan","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Research Center for Health Technology Assessment and Medical Informatics, School of Public Health Shahid Sadoughi University of Medical Sciences Yazd Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7225-2499","authenticated-orcid":false,"given":"Mohammad","family":"Rezaeisadrabadi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care, School of Medicine Isfahan University of Medical Sciences Isfahan Iran"},{"name":"Resident of Gastroenterology and Liver Disease Subspecialty Isfahan University of Medical Sciences Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2002032"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30183-5"},{"key":"e_1_2_10_4_1","unstructured":"World Health Orgamization. WHO coronavirus disease (COVID\u201019) dashboard. World Health Orgamization; 2021."},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.586073"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.26811"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1477"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep10942"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2004.02415.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.2991\/chi.k.210117.001"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000342379"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000369377"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-03215-8"},{"issue":"2","key":"e_1_2_10_14_1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1159\/000509107","article-title":"Early hemoperfusion for cytokine removal may contribute to prevention of intubation in patients infected with COVID\u201019","volume":"50","author":"Esmaeili Vardanjani A","year":"2021","journal-title":"Blood Purif"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra020528"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.2920100403"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000064742.00981.14"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2020.105974"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n861"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.7326\/M18-0850"},{"key":"e_1_2_10_21_1","volume-title":"Evidence\u2010based Practice in Nursing & Healthcare: A Guide to Best Practice","author":"Melnyk BM","year":"2011"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-020-02020-3"},{"key":"e_1_2_10_23_1","article-title":"Plasma exchange for COVID\u201019 thrombo\u2010inflammatory disease","author":"Arulkumaran N","year":"2020","journal-title":"EJHaem"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000004613"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pulmoe.2020.10.017"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16890"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2020.106188"},{"key":"e_1_2_10_28_1","first-page":"1","article-title":"Hemoperfusion as a potential treatment for critically ill COVID\u201019 patients with cytokine storm","volume":"50","author":"Shadvar K","year":"2020","journal-title":"Blood Purif"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-03171-3"},{"key":"e_1_2_10_30_1","first-page":"187","article-title":"Polymyxin B hemoperfusion in coronavirus disease 2019 patients with endotoxic shock: case series from EUPHAS2 registry","volume":"45","author":"De Rosa S","year":"2020","journal-title":"Artif Organs"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.26630"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2020.04.023"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2020.04.024"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13730-020-00538-x"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21861"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.2147\/IMCRJ.S263127"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1159\/000511725"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2020.08.2123"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2020.05.022"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcr2.679"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2020.108408"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.27182","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmv.27182","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.27182","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T22:56:37Z","timestamp":1693004197000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.27182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,13]]},"references-count":40,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1002\/jmv.27182"],"URL":"https:\/\/doi.org\/10.1002\/jmv.27182","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,13]]},"assertion":[{"value":"2021-05-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}