{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T03:31:22Z","timestamp":1782185482058,"version":"3.54.5"},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T00:00:00Z","timestamp":1626393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Coronavirus disease\u20102019 (COVID\u201019) is a respiratory disease whose clinical manifestation ranges from asymptomatic to severe respiratory failure. The purpose of this study was to investigate the place of serum surfactant\u2010D (SP\u2010D) and angiopoetin\u20102 (Ang\u20102) levels in predicting severity of disease in patients diagnosed with COVID\u201019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty\u2010four patients diagnosed with COVID\u201019 between September 2020 and February 2021, 50 patients diagnosed with community\u2010acquired pneumonia and a 50\u2010member healthy control group were included in the study. Plasma samples and clinical data were collected within 72\u2009h after admission, during hospital stay. Serum SP\u2010D and Ang\u20102 concentrations were measured using the enzyme\u2010linked immunosorbent assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>SP\u2010D and Ang\u20102 levels were significantly higher in the mild\u2013moderate pneumonia and severe\/critical patient groups compared to the asymptomatic and noncomplicated COVID\u201019 patients (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001 for all groups). Serum SP\u2010D and Ang\u20102 levels of severe\u2010critical COVID\u201019 patients were significantly higher than CAP patients (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Powerful correlation was present between clinical severity of COVID\u201019 and SP\u2010D and Ang\u20102 levels (<jats:italic>r<\/jats:italic>\u2009=\u20090.885 <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001 and <jats:italic>r<\/jats:italic>\u2009=\u20090.913 <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, respectively). Cut\u2010off values of 37.7\u2009ng\/ml (AUC\u2009=\u20090.763, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, 95% confidence interval [CI]\u2009=\u20090.667\u20130.860) for SP\u2010D and 4208.3\u2009pg\/ml (AUC\u2009=\u20090.659, <jats:italic>p<\/jats:italic>\u2009=\u20090.004, 95% CI\u2009=\u20090.554\u20130.763) for Ang\u20102 were identified as predictors of COVID\u201019 disease at receiver operating characteristic curve analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SP\u2010D and Ang\u20102 are predictive factors in differentiating COVID\u201019 patients and determining severity of disease. These data may be important for the initiation of treatment in the early stage of the disease in patients with COVID\u201019.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.27184","type":"journal-article","created":{"date-parts":[[2021,7,7]],"date-time":"2021-07-07T15:28:04Z","timestamp":1625671684000},"page":"6008-6015","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["The role of angiopoietin\u20102 and surfactant protein\u2010D levels in SARS\u2010CoV\u20102\u2010related lung injury: A prospective, observational, cohort study"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4406-014X","authenticated-orcid":false,"given":"Handan","family":"Alay","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine Ataturk University  Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5189-3564","authenticated-orcid":false,"given":"Esra","family":"Laloglu","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Medicine Ataturk University  Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,16]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"World Health Organization. Director\u2010General's remarks at the media briefing on 2019\u2010nCoV on 11 February 2020.http:\/\/www.who.int\/dg\/speeches\/detail\/who-director-general-s-remarks-at-the-media-briefing-on-2019-ncov-on-11-february-2020. Accessed March 12 2021."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30211-7"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2018.00018"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc13080"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cocis.2020.101413"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31305-2"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-03062-7"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a006650"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201708-1733OC"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2015.01.022"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0238160"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.B2000083"},{"key":"e_1_2_8_14_1","unstructured":"Republic of Turkey Ministry of Health General Directorate of Public Health. COVID\u201019 (SARS\u2010CoV\u20102 INFECTION). Adult Patient Treatment.https:\/\/covid19bilgi.saglik.gov.tr\/depo\/rehberler\/covid-19-rehberi\/COVID-19_REHBERI_ERISKIN_HASTA_TEDAVISI.pdf"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.2648"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2013020"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201908-1581ST"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00015.2006"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00081102"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-7-13"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-014-9669-3"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.117080"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30566-3"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14768"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1086\/428577"},{"issue":"1","key":"e_1_2_8_26_1","article-title":"Lymphopenia predicts disease severity of COVID\u201019: a descriptive and predictive study","volume":"5","author":"Tan Li","year":"2020","journal-title":"Signal Transduction and Targeted Therapy"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25871"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2020-0369"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1521-6616(03)00042-1"},{"key":"e_1_2_8_30_1","first-page":"1","article-title":"Are serum interleukin 6 and surfactant protein D levels associated with the clinical course of COVID\u201019?","volume":"12","author":"Kerget B","year":"2020","journal-title":"Lung"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-020-09730-0"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753466620905274"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.27184","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmv.27184","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.27184","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T22:54:02Z","timestamp":1693004042000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.27184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,16]]},"references-count":31,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1002\/jmv.27184"],"URL":"https:\/\/doi.org\/10.1002\/jmv.27184","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,16]]},"assertion":[{"value":"2021-06-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}