{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T17:25:53Z","timestamp":1793985953825,"version":"4.8.0"},"reference-count":41,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T00:00:00Z","timestamp":1629763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Only a few treatments are approved for coronavirus disease\u20102019 (COVID\u201019) infections, with continuous debate about their clinical impact. Repurposing antiviral treatments might prove the fastest way to identify effective therapy.\u00a0This trial aimed to evaluate the efficacy and safety of sofosbuvir (SOF) plus daclatasvir (DCV) or ravidasvir (RDV) added to standard care (SOC) for patients with moderate and severe COVID\u201019 infection.\u00a0Multicentre parallel randomized controlled open\u2010label trial. One hundred and twenty eligible patients with moderate and severe COVID\u201019 infection were randomized to one of the study arms.\u00a0Ten days of treatment with SOF plus DCV or RDV in addition to the standard of care compared to SOC. Follow up in 7 days.\u00a0Sum of the counted symptoms at 7 and 10 days, mean change in oxygen saturation level, viral negativity, and rate of intensive care unit (ICU) admission.\u00a0Compared to SOC, the SOF\u2010DCV group experienced a significantly lower sum of the counted symptoms (fever, headache, generalized aches, or respiratory distress) combined with no evidence of deterioration (ICU admission and mechanical ventilation) on Days 7 and 10 of treatment. Oxygen saturation also significantly improved among the SOF\u2010DCV group compared to SOC starting from Day 4. The study also showed positive trends regarding the efficacy of SOF\u2010DCV with a lower incidence of mortality. On the other hand, adding SOF\u2010RDV to SOC did not show significant improvements in endpoints.\u00a0The results support the efficacy and safety of SOF\u2010DCV as an add\u2010on to SOC for the treatment of moderate to severe COVID\u201019 infections.<\/jats:p>","DOI":"10.1002\/jmv.27264","type":"journal-article","created":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T13:45:12Z","timestamp":1628689512000},"page":"6750-6759","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Efficacy and safety of sofosbuvir plus daclatasvir or ravidasvir in patients with COVID\u201019: A randomized controlled trial"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0673-9557","authenticated-orcid":false,"given":"Sherif","family":"Abbass","sequence":"first","affiliation":[{"name":"National Liver Institute Shebeen El\u2010Kom Menoufia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2242-3640","authenticated-orcid":false,"given":"Ehab","family":"Kamal","sequence":"additional","affiliation":[{"name":"Medical Research Division, National\u00a0Research\u00a0Centre Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohsen","family":"Salama","sequence":"additional","affiliation":[{"name":"National Liver Institute Shebeen El\u2010Kom Menoufia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tary","family":"Salman","sequence":"additional","affiliation":[{"name":"National Liver Institute Shebeen El\u2010Kom Menoufia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyaa","family":"Sabry","sequence":"additional","affiliation":[{"name":"National Liver Institute Shebeen El\u2010Kom Menoufia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wael","family":"Abdel\u2010Razek","sequence":"additional","affiliation":[{"name":"National Liver Institute Shebeen El\u2010Kom Menoufia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherine","family":"Helmy","sequence":"additional","affiliation":[{"name":"Pharco Corporate Alexandria Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Abdelgwad","sequence":"additional","affiliation":[{"name":"National Liver Institute Shebeen El\u2010Kom Menoufia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neamt","family":"Sakr","sequence":"additional","affiliation":[{"name":"National Liver Institute Shebeen El\u2010Kom Menoufia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Elgazzar","sequence":"additional","affiliation":[{"name":"National Liver Institute Shebeen El\u2010Kom Menoufia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Einar","sequence":"additional","affiliation":[{"name":"Mahalla Fever Hospital Gharbia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Farouk","sequence":"additional","affiliation":[{"name":"Shebin Fever Hospital Menoufia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mounir","family":"Saif","sequence":"additional","affiliation":[{"name":"Menouf Fever Hospital Menoufia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismail","family":"Shehab","sequence":"additional","affiliation":[{"name":"Menouf Fever Hospital Menoufia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eman","family":"El\u2010hosieny","sequence":"additional","affiliation":[{"name":"Mahalla Fever Hospital Gharbia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai","family":"Mansour","sequence":"additional","affiliation":[{"name":"Shebin Fever Hospital Menoufia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doaa","family":"Mahdi","sequence":"additional","affiliation":[{"name":"Menouf Fever Hospital Menoufia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El\u2010Sayed","family":"Tharwa","sequence":"additional","affiliation":[{"name":"National Liver Institute Shebeen El\u2010Kom Menoufia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa","family":"Salah","sequence":"additional","affiliation":[{"name":"TCD MENA Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ola","family":"Elrouby","sequence":"additional","affiliation":[{"name":"Pharco Corporate Alexandria Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imam","family":"Waked","sequence":"additional","affiliation":[{"name":"National Liver Institute Shebeen El\u2010Kom Menoufia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,24]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"WHO. 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