{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T23:00:31Z","timestamp":1782774031495,"version":"3.54.5"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T00:00:00Z","timestamp":1629849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      This study aimed to determine the frequency of SARS\u2010CoV\u20102 RNA in serum and its association with the clinical severity of COVID\u201019. This retrospective cohort study performed at Toyama University Hospital included consecutive patients with confirmed COVID\u201019. The prevalence of SARS\u2010CoV\u20102 RNAemia and the strength of its association with clinical severity variables were examined. Fifty\u2010six patients were included in this study. RNAemia was detected in 19.6% (11\/56) patients on admission, and subsequently in 1.0% (1\/25), 50.0% (6\/12), and 100.0% (4\/4) moderate, severe, and critically ill patients, respectively. Patients with RNAemia required more frequent oxygen supplementation (90.0% vs. 13.3%), ICU admission (81.8% vs. 6.7%), and invasive mechanical ventilation (27.3% vs. 0.0%). Among patients with RNAemia, the median viral loads of nasopharyngeal (NP) swabs that were collected around the same time as the serum sample were significantly higher in critically ill (5.4 log\n                      <jats:sub>10<\/jats:sub>\n                      copies\/\u03bcl; interquartile range [IQR]: 4.2\u20136.3) than in moderate\u2010severe cases (2.6 log\n                      <jats:sub>10<\/jats:sub>\n                      copies\/\u03bcl; [IQR: 1.1\u20134.5];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.030) and were significantly higher in nonsurvivors (6.2 log\n                      <jats:sub>10<\/jats:sub>\n                      copies\/\u03bcl [IQR: 6.0\u20136.5]) than in survivors (3.9 log\n                      <jats:sub>10<\/jats:sub>\n                      copies\/\u03bcl [IQR: 1.6\u20134.6];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.045). This study demonstrated a relatively high proportion of SARS\u2010CoV\u20102 RNAemia and an association between RNAemia and clinical severity. Moreover, among the patients with RNAemia, the viral loads of NP swabs were correlated with disease severity and mortality, suggesting the potential utility of combining serum testing with NP tests as a prognostic indicator for COVID\u201019, with higher quality than each separate test.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmv.27282","type":"journal-article","created":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T14:24:27Z","timestamp":1629383067000},"page":"147-153","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["SARS\u2010CoV\u20102 RNAemia with a higher nasopharyngeal viral load is strongly associated with disease severity and mortality in patients with COVID\u201019"],"prefix":"10.1002","volume":"94","author":[{"given":"Hitoshi","family":"Kawasuji","sequence":"first","affiliation":[{"name":"Department of Clinical Infectious Diseases, Toyama University Graduate School of Medicine and Pharmaceutical Sciences University of Toyama  Toyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitomo","family":"Morinaga","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Toyama University Graduate School of Medicine and Pharmaceutical Sciences University of Toyama  Toyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Tani","sequence":"additional","affiliation":[{"name":"Department of Virology Toyama Institute of Health  Toyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Toyama University Graduate School of Medicine and Pharmaceutical Sciences University of Toyama  Toyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Takegoshi","sequence":"additional","affiliation":[{"name":"Department of 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