{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:09:33Z","timestamp":1792638573617,"version":"4.5.0"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T00:00:00Z","timestamp":1630281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>The burden of pneumonia, especially that caused by respiratory viruses, is markedly high in the pediatric age group. This study aimed to assess viral agents causing severe pneumonia among mechanically ventilated patients. Nonbronchoscopic bronchoalveolar lavage was performed for pediatric patients having severe pneumonia indicated for mechanical ventilation to be tested with a multiplex PCR immediate diagnosis of their etiologic pathogen. Among the 75 patients recruited, viral agents were detected in 73.4% of cases. Rhinovirus and respiratory syncytial virus (RSV) were the most common viruses detected in 32.1% and 29.5%, respectively. The rate of viral infection showed a clear increased incidence in the winter season. The mortality rate among viral\u2010associated severe pneumonia reached 56.36%. Odds of mortality increased threefolds in presence of comorbid conditions and 10\u2010folds with congenital heart disease. The study demonstrated the neglected importance of rhinovirus besides RSV in causing severe critical pneumonia in\u00a0the pediatric age.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.27284","type":"journal-article","created":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T12:51:47Z","timestamp":1629463907000},"page":"461-468","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Respiratory viruses associated with severe mechanically ventilated pneumonia in children"],"prefix":"10.1002","volume":"94","author":[{"given":"Ahmed","family":"El\u2010Nawawy","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, El\u2010Shatby Children's Hospital Alexandria Alexandria University  Alexandria Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manal AM.","family":"Antonios","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, El\u2010Shatby Children's Hospital Alexandria Alexandria University  Alexandria Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa A.","family":"Meheissen","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immuology, Faculty of Medicine Alexandria University  Alexandria Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwan M.","family":"Fahim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, El\u2010Shatby Children's Hospital Alexandria Alexandria University  Alexandria Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,30]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"SpecterMAfter Ebola. The New Yorker J2014; (https:\/\/www.newyorker.com\/news\/daily-comment\/whats-ebola)."},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61901-1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)30721-4"},{"issue":"2","key":"e_1_2_9_5_1","first-page":"153","article-title":"Viral pneumonia","volume":"12","author":"Freeman AM","year":"2019","journal-title":"StatPearls Publishing"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/14787210.2016.1233814"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(16)00060-6"},{"key":"e_1_2_9_8_1","unstructured":"Pediatric Ventilator\u2010Associated Event (PedVAE).Device\u2010associated Module. Center of Disease Prevention & Control (CDC). (https:\/\/www.cdc.gov\/nhsn\/pdfs\/pscmanual\/pcsmanual_current.pdf"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3758\/BF03193146"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1086\/422996"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3181f232fe"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.675"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1405870"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2015-206933"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.13.124412"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0124122"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2016.11.012"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.7189\/jogh.05.010408"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3181723751"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir043"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000002319"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1077"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001776"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18030623"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13052-021-00966-0"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.4274\/jpr.90532"},{"key":"e_1_2_9_27_1","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1542\/peds.146.1MA7.599b","article-title":"Mortality among children with heart disease and adenovirus pneumonia","volume":"146","author":"Crawford RL","year":"2020","journal-title":"Pediatrics"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.27284","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmv.27284","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.27284","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T07:10:52Z","timestamp":1692947452000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.27284"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,30]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1002\/jmv.27284"],"URL":"https:\/\/doi.org\/10.1002\/jmv.27284","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,30]]},"assertion":[{"value":"2021-06-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}