{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T01:33:15Z","timestamp":1793928795639,"version":"4.8.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T00:00:00Z","timestamp":1630972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    There is an established literature on the symptoms and complications of COVID\u201019 but the after\u2010effects of COVID\u201019 are not well understood with few studies reporting persistent symptoms and quality of life. We aim to evaluate the pooled prevalence of poor quality of life in post\u2010acute COVID\u201019 syndrome (PCS) and conducted meta\u2010regression to evaluate the effects of persistent symptoms and intensive care unit (ICU) admission on the poor quality of life. We extracted data from observational studies describing persistent symptoms and quality of life in post\u2010COVID\u201019 patients from March 10, 2020, to March 10, 2021, following PRISMA guidelines with a consensus of two independent reviewers. We calculated the pooled prevalence with 95% confidence interval (CI) and created forest plots using random\u2010effects models. A total of 12 studies with 4828 PCS patients were included. We found that amongst PCS patients, the pooled prevalence of poor quality of life (EQ\u2010VAS) was (59%; 95% CI: 42%\u201375%). Based on individual factors in the EQ\u20105D\u20105L questionnaire, the prevalence of mobility was (36, 10\u201367), personal care (8, 1\u201321), usual quality (28, 2\u201365), pain\/discomfort (42, 28\u201355), and anxiety\/depression (38, 19\u201358). The prevalence of persistent symptoms was fatigue (64, 54\u201373), dyspnea (39.5, 20\u201360), anosmia (20, 15\u201324), arthralgia (24.3, 14\u201336), headache (21, 3\u201347), sleep disturbances (47, 7\u201389), and mental health (14.5, 4\u201329). Meta\u2010regression analysis showed the poor quality of life was significantly higher among post\u2010COVID\u201019 patients with ICU admission (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.004) and fatigue (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0015). Our study concludes that PCS is associated with poor quality of life, persistent symptoms including fatigue, dyspnea, anosmia, sleep disturbances, and worse mental health. This suggests that we need more research on PCS patients to understand the risk factors causing it and eventually leading to poor quality of life.\n                  <\/jats:p>","DOI":"10.1002\/jmv.27309","type":"journal-article","created":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T09:19:12Z","timestamp":1630401552000},"page":"253-262","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":597,"title":["Post\u2010acute COVID\u201019 syndrome (PCS) and health\u2010related quality of life (HRQoL)\u2014A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9427-0225","authenticated-orcid":false,"given":"Preeti","family":"Malik","sequence":"first","affiliation":[{"name":"Department of Public Health Icahn school of Medicine at Mount Sinai New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karan","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Medicine Cooper Medical School of Rowan University Camden New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candida","family":"Pinto","sequence":"additional","affiliation":[{"name":"Department of Public Health Icahn school of Medicine at Mount Sinai New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richa","family":"Jaiswal","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Medical University of South Carolina Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raghavendra","family":"Tirupathi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Keystone Health Chambersburg Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shreejith","family":"Pillai","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Henry Ford Health System Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urvish","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Public Health Icahn school of Medicine at Mount Sinai New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,7]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"COVID\u201019 Coronavirus Pandemic. 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