{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:11:56Z","timestamp":1772118716767,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,9,12]],"date-time":"2021-09-12T00:00:00Z","timestamp":1631404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The ChAdOx1 nCoV\u201019 vaccine (Oxford University\u2010Astra Zeneca) has demonstrated nearly 70% efficacy against symptomatic COVID\u201019 in trials and some real\u2010world studies. The vaccine was the first to be approved in India in early January 2021 and is manufactured by the Serum Institute of India. Favorable short\u2010term safety data of the vaccine in India in a real\u2010world setting has been recently demonstrated. Here, we report secondary objective (COVID\u201019 occurrence) measures of the same ongoing prospective observational study in prioritized recipients of the vaccine. The findings are based on participants who could complete at least 2 months of follow\u2010up (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20091500; female\/male: 472\/1028; mean age: 38.8 years). Laboratory confirmed SARS\u2010CoV\u20102 infection was observed in 27\/65 participants (41%) who received a single dose and 271\/1435 (19%) who received both doses. Specifically, among doctors, 18\/27 (66.7%) one dose recipients and 131\/377 (34.7%) fully vaccinated developed SARS\u2010CoV\u20102 infection. The majority of the cases were mild in all groups, and most were breakthrough infections. The occurrence of \u201csevere\u201d COVID\u201019 was 7.7 times lower (0.4%) in fully vaccinated participants compared to partially vaccinated (3.1%). Four deaths were observed in the study. One of the four deaths was due to sepsis, two due to unspecified cardiac events, and one due to unspecified post\u2010COVID\u201019 complications. The results of this preliminary analysis necessitate vigorous research on the performance of vaccines against variants, optimal timing of vaccination, and also optimal timings of effectiveness studies to guide future vaccination policy.\n                  <\/jats:p>","DOI":"10.1002\/jmv.27320","type":"journal-article","created":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T09:00:25Z","timestamp":1631005225000},"page":"407-412","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Occurrence of COVID\u201019 in priority groups receiving ChAdOx1 nCoV\u201019 coronavirus vaccine (recombinant): A preliminary analysis from north India"],"prefix":"10.1002","volume":"94","author":[{"given":"Upinder","family":"Kaur","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Institute of Medical Sciences Banaras Hindu University  Varanasi Uttar Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sapna","family":"Bala","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, Institute of Medical Sciences Banaras Hindu University  Varanasi Uttar Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bisweswar","family":"Ojha","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Institute of Medical Sciences Banaras Hindu University  Varanasi Uttar Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0087-6235","authenticated-orcid":false,"given":"Sumit","family":"Jaiswal","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, Institute of Medical Sciences Banaras Hindu University  Varanasi Uttar Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sangeeta","family":"Kansal","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, Institute of Medical Sciences Banaras Hindu University  Varanasi Uttar Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7737-0016","authenticated-orcid":false,"given":"Sankha S.","family":"Chakrabarti","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, Institute of Medical Sciences Banaras Hindu University  Varanasi Uttar Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2021.101038"},{"key":"e_1_2_9_3_1","unstructured":"Ministry of Health and Family Welfare Government of India. Updated clinical management protocol for COVID\u201019. Accessed September 20 2020.https:\/\/www.mohfw.gov.in\/pdf\/UpdatedClinicalManagementProtocolforCOVID19dated03072020.pdf"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32661-1"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n1088"},{"key":"e_1_2_9_6_1","article-title":"Vaccine effectiveness of the first dose of ChAdOx1 nCoV\u201019 and BNT162b2 against SARS\u2010CoV\u20102 infection in residents of long\u2010term care facilities (VIVALDI study)","author":"Shrotri M","year":"2021","journal-title":"medRxiv"},{"issue":"21","key":"e_1_2_9_7_1","first-page":"00379","article-title":"Effectiveness of mRNA\u2010BNT162b2, mRNA\u20101273, and ChAdOx1 nCoV\u201019 vaccines against COVID\u201019 in healthcare workers: an observational study using surveillance data","volume":"1198","author":"Paris C","year":"2021","journal-title":"Clin Microbiol Infect"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2021.06.003"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2107808"},{"key":"e_1_2_9_10_1","unstructured":"Indian SARS\u2010CoV\u20102 Genomics Consortium (INSACOG). State\u2010wise VOCs. 2021. Accessed 1 September 2021.https:\/\/dbtindia.gov.in\/sites\/default\/files\/INSACOGKeyAspects.pdf\u00a0"},{"key":"e_1_2_9_11_1","unstructured":"SadamR. Delta variant behind India's 2nd wave 7 strains circulating in & around Varanasi study finds.2021. Accessed September 1 2021.https:\/\/theprint.in\/health\/delta-variant-behind-indias-2nd-wave-7-strains-circulating-in-around-varanasi-study-finds\/672288\/"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2021.26.27.2100626"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2108891"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03777-9"},{"issue":"21","key":"e_1_2_9_15_1","first-page":"00271","article-title":"ChAdOx1 nCoV\u201019 effectiveness during an unprecedented surge in SARS COV\u20102 infections","volume":"0953","author":"Satwik R","year":"2021","journal-title":"Eur J Intern Med"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.27320","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmv.27320","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.27320","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T13:45:06Z","timestamp":1692971106000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.27320"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,12]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1002\/jmv.27320"],"URL":"https:\/\/doi.org\/10.1002\/jmv.27320","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-772465\/v1","asserted-by":"object"}]},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,12]]},"assertion":[{"value":"2021-08-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}