{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T23:11:39Z","timestamp":1768345899031,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,9,18]],"date-time":"2021-09-18T00:00:00Z","timestamp":1631923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Serum hepatitis B core antibody (anti\u2010HBc) is associated with liver inflammation in chronic hepatitis B patients. This study aimed to investigate whether anti\u2010HBc could serve as a predictor of significant liver inflammation in hepatitis B e antigen (HBeAg)\u2010negative chronic hepatitis B virus (HBV) infected patients with normal alanine aminotransferase (ALT) and detectable HBV DNA. Treatment\u2010na\u00efve HBeAg\u2010negative chronic HBV infected patients with normal ALT and detectable HBV DNA who underwent liver biopsy were retrospectively included from two medical centers. Liver inflammation grade was evaluated using the Scheuer scoring system and significant liver inflammation was defined as \u2265G2. Serum anti\u2010HBc levels were measured by commercial immunoassays (Abbott GmbH &amp; Co. KG). A total of 117 patients were included and 50 (42.7%) patients showed significant liver inflammation. Serum anti\u2010HBc levels in patients with significant liver inflammation were significantly higher than patients with no or mild liver inflammation (&lt;G2) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). High serum anti\u2010HBc (odds ratio 1.562, 95% confidential interval 1.157\u20132.110, <jats:italic>p<\/jats:italic>\u2009=\u20090.004) was an independent risk factor of significant liver inflammation. The area under the receiver operating characteristic curve of serum anti\u2010HBc in predicting significant liver inflammation was 0.769 and the optimal cut\u2010off value was 10.87 S\/CO, with a sensitivity of 59.2% and a specificity of 87.9%. Our data revealed that a substantial of HBeAg\u2010negative chronic infection patients with normal ALT and detectable HBV DNA showed significant liver inflammation. Serum anti\u2010HBc can predict significant liver inflammation in these patients.<\/jats:p>","DOI":"10.1002\/jmv.27327","type":"journal-article","created":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T13:18:05Z","timestamp":1631193485000},"page":"659-666","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Association of anti\u2010HBc and liver inflammation in HBeAg\u2010negative chronic hepatitis B virus\u2010infected patients with normal ALT and detectable HBV DNA"],"prefix":"10.1002","volume":"94","author":[{"given":"Kefang","family":"Yao","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University Nanjing Jiangsu China"},{"name":"Department of Infectious Diseases, Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School Nanjing Jiangsu 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