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By the summer of 2020, as deaths from the disease declined nationally, multiple single\u2010center studies began to report declining mortality of patients with COVID\u201019. To evaluate the effect of COVID\u201019 on hospital\u2010based mortality, we searched the Vizient Clinical Data Base for outcomes data from approximately 600 participating hospitals, including 130 academic medical centers, from January 2017 through December 2020. More than 32 million hospital admissions were included in the analysis. After an initial spike, mortality from COVID\u201019 declined in all regions of the country to under 10% by June 2020 and remained constant for the remainder of the year. Despite this, inpatient, all\u2010cause mortality has increased since the beginning of the pandemic, even those without respiratory failure. Inpatient mortality has particularly increased in elderly patients and in those requiring intubation for respiratory failure. Since June 2020, COVID\u201019 kills one in every 10 patients admitted to the hospital with this diagnosis. The addition of this new disease has raised overall hospital mortality especially those who require intubation for respiratory failure.<\/jats:p>","DOI":"10.1002\/jmv.27332","type":"journal-article","created":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T13:49:42Z","timestamp":1631540982000},"page":"318-326","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Effect of mortality from COVID\u201019 on inpatient outcomes"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9329-5455","authenticated-orcid":false,"given":"Matthew C.","family":"Phillips","sequence":"first","affiliation":[{"name":"Los Angeles County + University of Southern California (LAC + USC) Medical Center Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Sarff","sequence":"additional","affiliation":[{"name":"Los Angeles County + University of Southern California (LAC + USC) Medical Center Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josh","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Los Angeles County + University of Southern California (LAC + USC) Medical Center Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chase","family":"Coffey","sequence":"additional","affiliation":[{"name":"Los Angeles County + University of Southern California (LAC + USC) Medical Center Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Holtom","sequence":"additional","affiliation":[{"name":"Los Angeles County + University of Southern California (LAC + USC) Medical Center Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve","family":"Meurer","sequence":"additional","affiliation":[{"name":"Vizient, Inc. 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