{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:44:57Z","timestamp":1791308697307,"version":"4.3.1"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T00:00:00Z","timestamp":1632787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Few studies have focused on the effect of hepatitis E virus (HEV) infection on gut microbiota. To explore the relationship between changes in gut microbiota\u00a0and inflammatory factors and viral load, we conducted a comparative study of 33 patients with acute hepatitis E (AHE) patients and 25 healthy controls (HCs) using high\u2010throughput 16S ribosomal ribonucleic acid gene sequencing. Shannon and Simpson's indices showed no significant differences in bacterial diversity between the AHE and HCs groups.\n                    <jats:italic>Proteobacteria<\/jats:italic>\n                    ,\n                    <jats:italic>Gammaproteobacteria<\/jats:italic>\n                    , and\n                    <jats:italic>Enterobacteriaceae<\/jats:italic>\n                    were most abundant in the AHE group, which contributed to the difference between the gut microbiota of the AHE and HCs groups, and the same difference between the HEV\u2010RNA\u2010positive and HEV\u2010RNA\u2010negative groups. Functional prediction analysis showed that ribosome, purine metabolism, and two\u2010component system were the top three pathways. Compared with the AHE group with normal interferon (IFN)\u2010\u03b3,\n                    <jats:italic>Proteobacteria<\/jats:italic>\n                    ,\n                    <jats:italic>Gammaproteobacteria<\/jats:italic>\n                    ,\n                    <jats:italic>Xanthomonadaceae<\/jats:italic>\n                    , and\n                    <jats:italic>Enterobacteriaceae<\/jats:italic>\n                    were more abundant in the high\u2010IFN\u2010\u03b3 group. The abundance of\n                    <jats:italic>Gammaproteobacteria<\/jats:italic>\n                    was positively correlated with the level of serum alanine transaminase and total bilirubin. The abundance of\n                    <jats:italic>Gammaproteobacteria<\/jats:italic>\n                    could discriminate AHE patients from HCs, and could better predict the severity of AHE patients. We believe that our findings will contribute toward a novel treatment strategy for AHE.\n                  <\/jats:p>","DOI":"10.1002\/jmv.27356","type":"journal-article","created":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T08:18:58Z","timestamp":1632298738000},"page":"692-702","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Gut microbiota dysbiosis associated with plasma levels of Interferon\u2010\u03b3 and viral load in patients with acute hepatitis E infection"],"prefix":"10.1002","volume":"94","author":[{"given":"Jian","family":"Wu","sequence":"first","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou China"},{"name":"Department of Clinical Laboratory, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School Nanjing Medical University Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariza","family":"Bortolanza","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine V\u2010Pulmonology, Allergology, Respiratory Intensive Care Medicine Saarland University Hospital Homburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanghua","family":"Zhai","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School Nanjing Medical University Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anquan","family":"Shang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Shanghai Tongji Hospital Tongji University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongxin","family":"Ling","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine The Central Blood Station of Yancheng City Yancheng China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochen","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Health Examination Center The First People's Hospital of Yancheng City Yancheng China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwen","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine V\u2010Pulmonology, Allergology, Respiratory Intensive Care Medicine Saarland University Hospital Homburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiong","family":"Yu","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9186-4741","authenticated-orcid":false,"given":"Lanjuan","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6604-6867","authenticated-orcid":false,"given":"Hongcui","family":"Cao","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou China"},{"name":"Zhejiang Provincial Key Laboratory for Diagnosis and Treatment of Aging and Physic\u2010chemical Injury Diseases Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2020.1722759"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2021.198483"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v27.i20.2458"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.27121"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/v13060992"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/v13050909"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2706.203964"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v13.i5.557"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/mSystems.00384-21"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1039\/d1fo00857a"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hbpd.2020.01.003"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00248-010-9801-8"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-13-175"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.13344"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.14218\/JCTH.2020.00117"},{"key":"e_1_2_10_17_1","first-page":"6027361","article-title":"Th1\/Th2 cells and associated cytokines in acute hepatitis E and related acute liver failure","volume":"2020","author":"Jian Wu","year":"2020","journal-title":"J Immunol Res"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23072-5"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-021-01069-y"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.04.077"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-14177-z"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.11.029"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2020.11.010"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hbpd.2019.12.008"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2011.01078.x"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.569104"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-03327-1"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.00165"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.11.010"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.27356","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmv.27356","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.27356","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T03:12:57Z","timestamp":1692933177000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.27356"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,28]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1002\/jmv.27356"],"URL":"https:\/\/doi.org\/10.1002\/jmv.27356","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,28]]},"assertion":[{"value":"2021-06-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}