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In recent months, a fungal infection, mucormycosis has emerged with more fatal responses and significantly increased mortality rate. To measure the severity and potential alternative approaches against black fungus coinfection in COVID\u201019 patients,\u00a0PubMed, Google Scholar, World Health Organization (WHO) newsletters, and other online resources, based on the cases reported and retrospective observational analysis were searched from the years 2015\u20132021. The studies reporting mucormycosis with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS\u2010CoV\u20102) coinfection and\/or demonstrating potential risk factors, such as a history of diabetes mellitus or suppressed immune system were included, and reports published in non\u2010English language were excluded. More than 20 case reports and observational studies on black fungus coinfection in COVID\u201019 patients were eligible for inclusion. The results indicated that diabetes mellitus, hyperglycemic, and immunocompromised COVID\u201019 patients with mucormycosis were at a higher risk. We found that it was prudent to assess the potential risk factors and severity of invasive mycosis via standardized diagnostic and clinical settings. Large\u2010scale studies need to be conducted to identify early biomarkers and optimization of diagnostic methods has to be established per population and geographical variation. This\u00a0will not only help clinicians around the world to detect the coinfection in time but also will prepare them for future outbreaks\u00a0of other potential pandemics.<\/jats:p>","DOI":"10.1002\/jmv.27358","type":"journal-article","created":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T21:13:37Z","timestamp":1632777217000},"page":"99-109","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["A systematic review on SARS\u2010CoV\u20102\u2010associated fungal\u00a0coinfections"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5620-9722","authenticated-orcid":false,"given":"Shringika","family":"Soni","sequence":"first","affiliation":[{"name":"Amity Institute of Nanotechnology (AINT) Amity University Uttar Pradesh (AUUP) Noida India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramesh","family":"Namdeo Pudake","sequence":"additional","affiliation":[{"name":"Amity Institute of Nanotechnology (AINT) Amity University Uttar Pradesh (AUUP) Noida India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3901-0153","authenticated-orcid":false,"given":"Utkarsh","family":"Jain","sequence":"additional","affiliation":[{"name":"Amity Institute of Nanotechnology (AINT) Amity University Uttar Pradesh (AUUP) Noida India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9512-1144","authenticated-orcid":false,"given":"Nidhi","family":"Chauhan","sequence":"additional","affiliation":[{"name":"Amity Institute of Nanotechnology (AINT) Amity University Uttar Pradesh (AUUP) Noida India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-021-00299-2"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n1124"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.riam.2020.07.001"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21134782"},{"key":"e_1_2_9_6_1","first-page":"1","article-title":"Optimizing testing regimes for the detection of COVID\u201019 in children and older adults","author":"Chauhan N","year":"2021","journal-title":"Expert Rev Mol Diagn"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmmb.2020.10.014"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2020.104436"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir864"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/349278"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2021.111643"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000001931"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13774"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2021.05.019"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2020.05.046"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.26709"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2020.06.025"},{"key":"e_1_2_9_18_1","unstructured":"International Diabetes Federation. 2020.https:\/\/idf.org\/our-network\/regions-members\/south-east-asia\/members\/94-india.html. 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