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The present study aims to evaluate the efficacy and safety of grazoprevir (GZR) plus elbasvir (EBR) treatment in acute hepatitis C (AHC) patients undergoing hemodialysis. Patients undergoing hemodialysis who had a nosocomial acute HCV infection were enrolled. All patients received GZR 100\u2009mg\/EBR 50\u2009mg once daily for 12 weeks and were followed up for 12 weeks. Serum alanine transaminase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL), and HCV RNA levels were monitored during treatment and follow\u2010up periods. Sustained virologic response at 12 weeks after treatment cessation and treatment\u2010emergent adverse events (AEs) were assessed. A total of 68 AHC patients were enrolled. All patients were infected with HCV genotype 1b and achieved SVR12. Decreasing ALT, AST, and TBIL were observed over time in the first 4 weeks and became steady thereafter. Forty\u2010eight (70.59%) patients reported at least one AEs. The most common AEs were fatigue, headache, and nausea. Two AHC patients discontinued treatment due to serious but drug\u2010unrelated AEs. In conclusion, GZR\/EBR has a high efficacy and safety profile in hemodialysis\u2010dependent patients with genotype 1b AHC.<\/jats:p>","DOI":"10.1002\/jmv.27374","type":"journal-article","created":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T10:55:58Z","timestamp":1633344958000},"page":"675-682","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Safety and efficacy of grazoprevir\/elbasvir in the treatment of acute hepatitis C in hemodialysis patients"],"prefix":"10.1002","volume":"94","author":[{"given":"Qinghua","family":"Ji","sequence":"first","affiliation":[{"name":"Department of Infectious Disease, School of Medicine Southeast University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xudong","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases The Affiliated Dongtai Hospital of Nantong University  Dongtai Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yugui","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory The Affiliated Dongtai Hospital of Nantong University  Dongtai Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory The Second Hospital of Nanjing  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, School of Medicine Southeast University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2680-320X","authenticated-orcid":false,"given":"Wei","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Liver Disease The Second Hospital of Nanjing, Southeast University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-018-0026-5"},{"key":"e_1_2_10_3_1","unstructured":"World Health Organization. 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