{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:06:23Z","timestamp":1791835583455,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,10,12]],"date-time":"2021-10-12T00:00:00Z","timestamp":1633996800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effect of the severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) Alpha variant (also known as B.1.1.7 lineage, 20I\/501Y.V1, the UK variant or VOC 202012\/01) infection on pregnancy is currently unknown.<\/jats:p><jats:p>We present a case of a 37\u2010year\u2010old woman admitted to our tertiary hospital at a gestational age of 29 weeks and 1 day because of oligohydramnios with reduced fetal movements for 10 days. About 20 days before admission, she tested positive for SARS\u2010CoV\u20102 Alpha variant. The following day, due to abnormal cardiotocography, increased brain sparing, and absent end\u2010diastolic flow in the umbilical artery, an urgent cesarean section was performed. The neonate had an uneventful admission to the neonatal intensive care unit. All neonatal samples proved negative for SARS\u2010CoV\u20102.<\/jats:p><jats:p>Pathological examination of the placenta revealed intervillous fibrin deposition, ischemic necrosis of villi and histiocytic intervillositis, corresponding with the SARS\u2010CoV\u20102 placentitis triad. The placental tissue demonstrated a high viral load, possibly explaining the acute onset of placental insufficiently and subsequent fetal distress.<\/jats:p><jats:p>This case demonstrates the importance of seeking medical care when experiencing reduced fetal movement in SARS\u2010CoV\u20102 infected patients since acute infection can induce significant placental and subsequent fetal pathology.<\/jats:p>","DOI":"10.1002\/jmv.27379","type":"journal-article","created":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T23:15:47Z","timestamp":1633734947000},"page":"1196-1200","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Acute SARS\u2010CoV\u20102 alpha variant infection leading to placental insufficiency and fetal distress"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5660-1591","authenticated-orcid":false,"given":"Sander","family":"Dumont","sequence":"first","affiliation":[{"name":"Department of Gynecology, Obstetrics, and Fertility AZ Sint\u2010Jan Brugge\u2010Oostende AV Brugge Belgium"},{"name":"Department of Gynecology and Obstetrics University Hospitals Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3002-8058","authenticated-orcid":false,"given":"Jonas","family":"Balduyck","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Obstetrics, and Fertility AZ Sint\u2010Jan Brugge\u2010Oostende AV Brugge Belgium"},{"name":"Department of Gynecology and Obstetrics University Hospitals Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2079-1279","authenticated-orcid":false,"given":"Marijke","family":"Reynders","sequence":"additional","affiliation":[{"name":"Department of Microbiology AZ Sint\u2010Jan Brugge\u2010Oostende AV Brugge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lieve","family":"Vanwalleghem","sequence":"additional","affiliation":[{"name":"Department of Pathology AZ Sint\u2010Jan Brugge\u2010Oostende AV Brugge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8671-878X","authenticated-orcid":false,"given":"Barbara","family":"Lebbe","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Obstetrics, and Fertility AZ Sint\u2010Jan Brugge\u2010Oostende AV Brugge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,12]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"World Health Organization. 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