{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T22:46:10Z","timestamp":1786833970038,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,11,4]],"date-time":"2021-11-04T00:00:00Z","timestamp":1635984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009947","name":"Merck Sharp and Dohme","doi-asserted-by":"publisher","award":["LKR193017"],"award-info":[{"award-number":["LKR193017"]}],"id":[{"id":"10.13039\/100009947","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Congenital cytomegalovirus infection (cCMVi) is the leading cause of nonhereditary sensorineural hearing loss among newborns. Women newly acquiring cytomegalovirus infection (CMVi) during pregnancy have the highest risk of vertical transmission. This study aimed to describe the epidemiology of CMVi in pregnancy in a large healthcare database. A retrospective cohort study was performed using the Maccabi Healthcare Services database (Israel). Women aged 18\u201344 years old on July 1, 2013 with no record of pregnancy in the prior 6 months were followed through December 31, 2017 for first pregnancy occurrence. Pregnancy outcomes (live birth, spontaneous\/therapeutic abortions, stillbirth, and uncertain outcomes) were captured. CMV test results were obtained to assess serostatus at the start of pregnancy (SoP) and primary CMV infection (CMVi) during pregnancy. Associations of demographic and reproductive factors with pCMVi were investigated (multivariable logistic regression). The study included 84\u2009699 pregnant women (median age\u2009=\u200931 years; interquartile range\u2009=\u200928\u201335). Live birth, fetal loss, and uncertain pregnancy outcomes accounted for 76.8%, 18.2%, and 5.0%, respectively. The seroprevalence of CMV at the start of pregnancy in this cohort was 63.4% (95% confidence interval [CI]: 63.1\u201363.7). Among seronegative women with available test results (<jats:italic>n<\/jats:italic>\u2009=\u200910\u2009657), CMVi incidence was 14.5 per 1000 (95% CI\u2009=\u200912.2\u201316.7). In multivariate logistic regression models adjusting for maternal age, CMVi was significantly associated with having one or more prior live births (odds ratio [OR]: 3.8 [95% CI: 2.6\u20135.4]) and having a child less than 6 years of age (OR: 4.3 [95%CI: 3.0\u20136.1]). One in three pregnant women in Israel is at risk for primary CMVi. This study demonstrates that real\u2010world electronic healthcare data can be leveraged to support clinical management and development of interventions for congenital CMV by identifying women at high risk for CMVi during pregnancy.<\/jats:p>","DOI":"10.1002\/jmv.27403","type":"journal-article","created":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T20:59:50Z","timestamp":1634763590000},"page":"713-719","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Epidemiology of cytomegalovirus infection in pregnancy in Israel: Real\u2010world data from a large healthcare organization"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0174-7208","authenticated-orcid":false,"given":"Clara","family":"Weil","sequence":"first","affiliation":[{"name":"Maccabi Institute for Research and Innovation (Maccabitech) Maccabi Healthcare Services Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efraim","family":"Bilavsky","sequence":"additional","affiliation":[{"name":"Schneider Children's Medical Center Petah Tikva Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anushua","family":"Sinha","sequence":"additional","affiliation":[{"name":"Merck &amp; Co., Inc. Kenilworth New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Chodick","sequence":"additional","affiliation":[{"name":"Maccabi Institute for Research and Innovation (Maccabitech) Maccabi Healthcare Services Tel Aviv Israel"},{"name":"Schneider Children's Medical Center Petah Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Goodman","sequence":"additional","affiliation":[{"name":"Merck &amp; Co., Inc. Kenilworth New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei (Vivian)","family":"Wang","sequence":"additional","affiliation":[{"name":"Merck &amp; Co., Inc. Kenilworth New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawna R.","family":"Calhoun","sequence":"additional","affiliation":[{"name":"Merck &amp; Co., Inc. Kenilworth New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan A.","family":"Marks","sequence":"additional","affiliation":[{"name":"Merck &amp; Co., Inc. Kenilworth New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00062-12"},{"key":"e_1_2_10_3_1","article-title":"Congenital cytomegalovirus infection: clinical features and diagnosis","author":"Demmler\u2010Harrison G","year":"2019","journal-title":"UpToDate"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.535"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/v10080405"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.02.018"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.659"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/apm.12899"},{"issue":"1","key":"e_1_2_10_9_1","first-page":"002","article-title":"Systematic serological cytomegalovirus screening in pregnancy: seroprevalence, seroconversion and frequency of congenital cytomegalovirus infection from 2007 to 2016","volume":"1","author":"Silvano P","year":"2020","journal-title":"J Nurs Midwifery"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268815003167"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-7-71"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1086\/508173"},{"key":"e_1_2_10_13_1","unstructured":"OECD. 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