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In the humoral response to the four seasonal coronaviruses, only HCoV\u2010HKU1\u2010 and HCoV\u2010229E\u2010assays showed slightly elevated antibody levels in the COVID group compared to the control group. While in the COVID\u2010group the levels of SARS\u2010CoV\u20102 antibodies correlated significantly with disease severity, no association was found in the levels of antibodies against the seasonal coronaviruses. The most striking result in both groups was that the levels of antibodies against all tested coronaviruses, including the new SARS\u2010CoV\u20102 showed a highly significant correlation with each other. There seems to be an individual predisposition to a weaker or stronger humoral immune response against all known seasonal human coronaviruses including the new SARS\u2010CoV\u20102, which could lead to a definition of low and high responders against human coronaviruses with potential impact on the assessment of postinfection antibody levels and protection.<\/jats:p>","DOI":"10.1002\/jmv.27427","type":"journal-article","created":{"date-parts":[[2021,10,30]],"date-time":"2021-10-30T10:27:23Z","timestamp":1635589643000},"page":"1096-1103","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Humoral response to SARS\u2010CoV\u20102 and seasonal coronaviruses in COVID\u201019 patients"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9194-8475","authenticated-orcid":false,"given":"Ortwin","family":"Adams","sequence":"first","affiliation":[{"name":"Institute for Virology, Medical Faculty 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