{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T20:09:36Z","timestamp":1775160576879,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,11,12]],"date-time":"2021-11-12T00:00:00Z","timestamp":1636675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Persistent infection of human Papillomavirus is the main etiological factor for cervical cancer. Austro\u2010Asiatic tribes are early settlers in India and they have unique genetic variations compared to other people. The immunological response is crucial for the prevention of viral associated diseases. Interleukin\u20101 receptor antagonist (IL\u20101RN) is considered being an important regulator of host immune surveillance. A total of 45 Santali tribal women and 10 Kora tribal women were enrolled in the present study and demographic variables were recorded during collection. Genomic DNA was extracted from cervical\/vaginal swab samples. IL1RN variable number of tandem repeats (VNTR) polymorphisms and HPV types were determined by PCR\u2010based assay. Association between IL1RN VNTR polymorphisms with the HPV infections among the tribal communities was determined by logistic regression analysis. HPV18 prevalence was significantly higher among tribal women. We observed that the polymorphism A2*A2 (<jats:italic>p<\/jats:italic>\u2009=\u20090.022; odds ratio [OR] (95% confidence interval [CI])\u2009=\u20090.16 (0.03\u20130.86)] were more resistant to oncogenic HPV infection. Use of oral contraceptives was associated with higher relative risk (<jats:italic>p<\/jats:italic>\u2009=\u20090.008; OR [95% CI]\u2009=\u20095.39 [1.47\u201319.8]) for oncogenic HPV18 positivity among the tribal women. The A2 allele homozygosity of IL1RN VNTR was identified to be associated with the protection from oncogenic HPV infection among various tribal communities of West Bengal and therefore may be a useful marker of host immune response among them.<\/jats:p>","DOI":"10.1002\/jmv.27436","type":"journal-article","created":{"date-parts":[[2021,11,6]],"date-time":"2021-11-06T13:14:13Z","timestamp":1636204453000},"page":"752-760","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The influence of IL1RN VNTR polymorphism on HPV infection among some tribal communities"],"prefix":"10.1002","volume":"94","author":[{"given":"Anindita","family":"Goswami","sequence":"first","affiliation":[{"name":"Biomedical Genetics Laboratory, Department of Zoology The University of Burdwan  Burdwan West Bengal India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Utpal","family":"Bhuniya","sequence":"additional","affiliation":[{"name":"Chakdighi Primary Health Centre, Health and Family Welfare Department Govt. of West Bengal  Burdwan West Bengal India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soumendranath","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Parasitology and Microbiology Research Laboratory, Department of Zoology The University of Burdwan  Burdwan West Bengal India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paramita","family":"Mandal","sequence":"additional","affiliation":[{"name":"Biomedical Genetics Laboratory, Department of Zoology The University of Burdwan  Burdwan West Bengal India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,11,12]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"http:\/\/censusindia.gov.in\/2011census\/populationenumeration.aspx"},{"key":"e_1_2_12_3_1","unstructured":"KosambiDD.The Culture and Civilisation of Ancient India in Historical Outline. 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