{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:41:10Z","timestamp":1763037670946},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T00:00:00Z","timestamp":1637107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Five percent of patients infected with SARS\u2010CoV\u20102 require advanced respiratory support. The high\u2010flow nasal cannula oxygenotherapy (HFNCO) appears to be effective and safe to reduce the need for mechanical ventilation. However, the factors associated with HFNCO failure as well as the outcomes of patients receiving this noninvasive respiratory strategy remain unclear. Thus, we performed this study to determine factors leading to intubation of SARS\u2010CoV\u20102 patients treated with HFNCO and patients\u2019 outcomes.\u00a0We retrospectively analyzed the medical charts of patients admitted in our ICU center for acute respiratory failure due to SARS\u2010CoV\u20102 infection and who initially benefited from HFNCO, between September 1, 2020, and March 1, 2021. We included all adults patients who received HFNCO and compared two groups: those treated with HFNCO alone and those who failed HFNCO. Patients treated with HFNCO and secondarily limited to the use of mechanical ventilation were excluded from the analysis. Sixty\u2010nine patients were included, 33 were treated with HFNCO alone and 36 failed HFNCO. We found more patients with shock in the HFNCO failure group (<jats:italic>p<\/jats:italic>\u2009=\u20090.001). The mean IGSII score was higher in the HFNCO failure group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The minimum PaO<jats:sub>2<\/jats:sub>\/FiO<jats:sub>2<\/jats:sub> was lower in the HFNCO failure group (<jats:italic>p<\/jats:italic>\u2009=\u20090.024). The length of stay in ICU was higher in the HFNCO failure group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The mean duration of HFNCO before intubation was 1.77 days. Six\u2010week mortality was higher in the HFNCO failure group (<jats:italic>p<\/jats:italic>\u2009=\u20090.034). Ten patients had a complication during intubation.\u00a0The HFNCO leads to reduce the intubation rate, the length of stay in ICU, and the mortality. Determining the factors associated with HFNCO failure is important to avoid complications following late intubation.<\/jats:p>","DOI":"10.1002\/jmv.27442","type":"journal-article","created":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T07:23:31Z","timestamp":1636529011000},"page":"1236-1240","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Factors associated with mechanical ventilation in SARS\u2010CoV\u20102 patients treated with high\u2010flow nasal cannula oxygen and outcomes"],"prefix":"10.1002","volume":"94","author":[{"given":"Xavier","family":"Leroux","sequence":"first","affiliation":[{"name":"Service de r\u00e9animation m\u00e9dicale \u00a0H\u00f4pital Pasteur de Colmar Colmar France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maud","family":"Schock","sequence":"additional","affiliation":[{"name":"Service de r\u00e9animation m\u00e9dicale \u00a0H\u00f4pital Pasteur de Colmar 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