{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T07:14:52Z","timestamp":1790493292690,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,11,13]],"date-time":"2021-11-13T00:00:00Z","timestamp":1636761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Immunocompromised patients have an increased risk of persistent COVID\u201019 disease. We report here the clinical course of two patients with hematologic malignancies hospitalized due to severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) infection. In both patients, viral evolution\u00a0including new spike gene mutations that occurred following treatment with anti\u2010SARS\u2010CoV\u20102 antibodies preparations, including convalescent plasma and bamlanivimab. These cases demonstrate the possibility of antibody\u2010resistant SARS\u2010CoV\u20102 infections evolution in immunocompromised patients.<\/jats:p>","DOI":"10.1002\/jmv.27445","type":"journal-article","created":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T07:24:21Z","timestamp":1636529061000},"page":"1241-1245","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Evolution of spike mutations following antibody treatment in two immunocompromised patients with persistent COVID\u201019 infection"],"prefix":"10.1002","volume":"94","author":[{"given":"Yotam","family":"Bronstein","sequence":"first","affiliation":[{"name":"Department of Internal Medicine D Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amos","family":"Adler","sequence":"additional","affiliation":[{"name":"Clinical Microbiology Laboratory Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haytham","family":"Katash","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine B Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ora","family":"Halutz","sequence":"additional","affiliation":[{"name":"Clinical Microbiology Laboratory Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yair","family":"Herishanu","sequence":"additional","affiliation":[{"name":"Department of Hematology Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia","family":"Levytskyi","sequence":"additional","affiliation":[{"name":"Clinical Microbiology Laboratory Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020008824"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.10.049"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2031670"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03291-y"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2008-3"},{"key":"e_1_2_8_7_1","article-title":"Acquisition and onward transmission of a SARS\u2010CoV\u20102 E484K variant among household contacts of a bamlanivimab\u2010treated patient","author":"Sabin AP","year":"2021","journal-title":"medRxiv"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciab392"},{"key":"e_1_2_8_9_1","article-title":"Emergence of SARS\u2010CoV\u20102 resistance with monoclonal antibody therapy","author":"Choudhary MC","year":"2021","journal-title":"medRxiv"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/v13081642"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2710.211509"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00741-21"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.61312"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00542-x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiaa446"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2021.06.006"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines9080937"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2710.211538"},{"issue":"21","key":"e_1_2_8_19_1","first-page":"00435","article-title":"Emergence of Q493R mutation in SARS\u2010CoV\u20102 spike protein during bamlanivimab\/etesevimab treatment and resistance to viral clearance","volume":"0163","author":"Guigon A","year":"2021","journal-title":"J Infect"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.27445","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmv.27445","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.27445","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T12:01:29Z","timestamp":1692878489000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.27445"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,13]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1002\/jmv.27445"],"URL":"https:\/\/doi.org\/10.1002\/jmv.27445","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,13]]},"assertion":[{"value":"2021-09-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}