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In this study, we aimed to characterize and identify which epidemiological, clinical, and paraclinical risk factors defined COVID\u201019 infection from the first confirmed cases through the first epidemic wave in Venezuela. A retrospective analysis of consecutive suspected cases of COVID\u201019 admitted to a sentinel hospital was carried out, including 576 patient cases subsequently confirmed for severe acute respiratory syndrome coronavirus 2 infection. Of these, 162 (28.1%) patients met the definition criteria for severe\/critical disease, and 414 (71.2%) were classified as mild\/moderate disease. The mean age was 47 (<jats:italic>SD<\/jats:italic> 16) years, the majority of which were men (59.5%), and the most frequent comorbidity was arterial hypertension (23.3%). The most common symptoms included fever (88.7%), headache (65.6%), and dry cough (63.9%). Severe\/critical disease affected mostly older males with low schooling (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Similarly, higher levels of glycemia, urea, aminotransferases, total bilirubin, lactate dehydrogenase, and erythrocyte sedimentation rate were observed in severe\/critical disease patients compared to those with mild\/moderate disease. Overall mortality was 7.6% (44\/576), with 41.7% (28\/68) dying in hospital. We identified risk factors related to COVID\u201019 infection, which could help healthcare providers take appropriate measures and prevent severe clinical outcomes. Our results suggest that the mortality registered by this disease in Venezuela during the first epidemic wave was underestimated. An increase in fatalities is expected to occur in the coming months unless measures that are more effective are implemented to mitigate the epidemic while the vaccination process is ongoing.<\/jats:p>","DOI":"10.1002\/jmv.27449","type":"journal-article","created":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T10:10:51Z","timestamp":1636625451000},"page":"1175-1185","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["First wave of COVID\u201019 in Venezuela: Epidemiological, clinical, and paraclinical characteristics of first cases"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8065-8464","authenticated-orcid":false,"given":"David A.","family":"Forero\u2010Pe\u00f1a","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases University Hospital of Caracas Caracas Venezuela"},{"name":"Department of Infectious Diseases Biomedical Research and Therapeutic 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