{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T04:33:40Z","timestamp":1793075620269,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T00:00:00Z","timestamp":1637712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T00:00:00Z","timestamp":1637712000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004704","name":"National Research Council of Thailand","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004704","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Effective vaccines are essential for controlling the coronavirus disease 2019 (COVID\u201019) pandemic. CoronaVac, which is an inactivated virus vaccine, was the first imported COVID\u201019 vaccine in Thailand. To investigate the safety and immunogenicity of CoronaVac within the Thai population, we conducted a prospective cohort study among health care workers aged 18\u201359 years, who received a 2\u2010dose regimen of CoronaVac 21 days apart between March and April 2021 at the hospital in Samut Sakhon, Thailand. We recruited 185 participants with a mean age of 32 years. Total antibodies against receptor\u2010binding domain (RBD) and immunoglobulin G (IgG) against nucleocapsid (N) protein of SARS\u2010CoV\u20102 were tested. Total antibodies against RBD were negative before immunization. One volunteer was positive for N, although negative for the RBD antibodies. The seroconversion rate of total antibodies against RBD after the first CoronaVac dose was 67% with a Geometric mean concentration (GMC) of 1.98 U\/ml. Following CoronaVac dose 2, the seroconversion rate increased to 100% with a GMC of 92.9 U\/ml. The seroconversion rates of IgG against N protein were 1% after dose 1 and 62.8% after dose 2. The overall incidence of adverse reactions was 59.5%. Injection\u2010site pain was the most common local adverse event (52.4%), while myalgia was the most common systemic adverse event (31.9%). No serious adverse events were observed. A 0\u201321 days, 2\u2010dose CoronaVac regimen appears safe, inducing a satisfactory response compared with convalescent serum obtained 4\u20136 weeks postnatural infection. Antibody responses after 2\u2010dose CoronaVac were comparable to the convalescent plasma but waned rapidly after 3 months. Therefore, we recommend 2\u2010dose CoronaVac administration with possible booster doses.<\/jats:p>","DOI":"10.1002\/jmv.27458","type":"journal-article","created":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T21:43:38Z","timestamp":1637012618000},"page":"1442-1449","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Safety and immunogenicity of inactivated COVID\u201019 vaccine in health care workers"],"prefix":"10.1002","volume":"94","author":[{"given":"Saovanee","family":"Benjamanukul","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Banphaeo General Hospital  Samut Sakhon Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasiwimon","family":"Traiyan","sequence":"additional","affiliation":[{"name":"Department of Pediatric, Allergy and Asthma Unit Banphaeo General Hospital  Samut Sakhon Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritthideach","family":"Yorsaeng","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Center of Excellence in Clinical Virology, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preeyaporn","family":"Vichaiwattana","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Center of Excellence in Clinical Virology, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natthinee","family":"Sudhinaraset","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Center of Excellence in Clinical Virology, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasamon","family":"Wanlapakorn","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Center of Excellence in Clinical Virology, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2337-6807","authenticated-orcid":false,"given":"Yong","family":"Poovorawan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Center of Excellence in Clinical Virology, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"},{"name":"FRS(T), The Royal Society of Thailand, Sanam Sueapa, Dusit  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2607.200282"},{"key":"e_1_2_10_3_1","unstructured":"World Health Organization. WHO coronavirus disease (COVID\u201019) dashboard.2021. Updated September 24 2021. Accessed September 26 2021.http:\/\/covid19.who.int\/"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.12968\/hmed.2020.0191"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2020.566212"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41562-021-01060-5"},{"key":"e_1_2_10_7_1","unstructured":"World Health Organization. Draft landscape of COVID\u201019 candidate vaccines. Updated September2021. Accessed September 2 6 2021http:\/\/www.who.int\/publications\/m\/item\/draft-landscape-of-covid-19-candidate-vaccines"},{"key":"e_1_2_10_8_1","unstructured":"World Health Organization. COVID\u201019 advice for the public: Getting vaccinated. Accessed September 18 2021.https:\/\/www.who.int\/emergencies\/diseases\/novel-coronavirus-2019\/covid-19-vaccines\/advice"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-00480-0"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.4110\/in.2021.21.e4"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2020.08.002"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfimm\/iqab010"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(20)30843-4"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(20)30987-7"},{"key":"e_1_2_10_15_1","unstructured":"World Health Organization. Covid\u201019 vero cell inactivated. Accessed September 26 2021.https:\/\/extranet.who.int\/pqweb\/sites\/default\/files\/documents\/COR-WHO-Adu-40_vials-insert.pdf"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abc1932"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-020-00789-5"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)01429-X"},{"key":"e_1_2_10_19_1","unstructured":"Food and Drug Administration Ministry of Public Health Thailand. Details of Medicinal Product. Accessed September 26 2021.https:\/\/extranet.who.int\/pqweb\/sites\/default\/files\/documents\/SINOVAC_TAG_PEG_REPORT_EUL-Final28june2021.pdf"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-021-01530-2"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.15543"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-021-00315-6"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.15125"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32466-1"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2035389"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2034577"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2021.05.041"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.27098"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-03041-6"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2034545"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2021.05.063"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21111-9"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0244126"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2020.05.008"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiab124"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2021.103561"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abf4063"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.27458","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmv.27458","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.27458","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T04:16:17Z","timestamp":1793074577000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.27458"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,24]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1002\/jmv.27458"],"URL":"https:\/\/doi.org\/10.1002\/jmv.27458","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,24]]},"assertion":[{"value":"2021-07-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}