{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T04:33:35Z","timestamp":1793075615178,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,11,27]],"date-time":"2021-11-27T00:00:00Z","timestamp":1637971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,11,27]],"date-time":"2021-11-27T00:00:00Z","timestamp":1637971200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Since the outbreak of COVID\u201019 in China, it has rapidly spread across many other countries. We evaluated antioxidant defense systems and inflammatory status related to the SARS\u2010CoV2 infection in a population from southwestern Iran. Comorbidities and clinical symptoms of 104 subjects (comprising negative and positive\u2010PCR COVID\u201019 outpatients) were assessed. Serum concentrations of glutathione reductase (GR) and interleukin\u201010 (IL\u201010) were measured using ELISA. In the positive\u2010PCR group, follow\u2010ups on clinical symptoms were carried out for 28 days at 7\u2010day intervals. In the positive\u2010PCR group, hypertension, diabetes, liver disease, chronic heart disease, and chronic kidney disease were the most common comorbidities. In the general category of symptoms, we found a significant difference between negative and positive\u2010PCR groups, except regarding runny noses. In the pulmonary category, there was a significant difference between the two groups except in terms of chest pain. We also determined a significant difference in neurologic symptoms, except for ear pain, between negative and positive\u2010PCR groups. We also found significantly lower levels of GR but higher levels of IL\u201010 in the positive\u2010PCR group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.000 for both). In the positive\u2010PCR group, serum levels of IL\u201010 (odds ratio\u2009=\u20090.914,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.012) decreased the chances of neurological symptoms occurring over time. The antioxidant defense systems of positive\u2010PCR outpatients failed as demonstrated by a reduction in the serum levels of GR. We also indicated a dysregulation in the immune response against COVID\u201019, characterized by changes in serum IL\u201010 levels.\n                  <\/jats:p>","DOI":"10.1002\/jmv.27464","type":"journal-article","created":{"date-parts":[[2021,11,20]],"date-time":"2021-11-20T09:37:27Z","timestamp":1637401047000},"page":"1457-1464","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Profiling serum levels of glutathione reductase and interleukin\u201010 in positive and negative\u2010PCR COVID\u201019 outpatients: A comparative study from southwestern Iran"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3616-6881","authenticated-orcid":false,"given":"Mahshid","family":"Naghashpour","sequence":"first","affiliation":[{"name":"Department of Nutrition, School of Medicine Abadan University of Medical Sciences Abadan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid","family":"Ghiassian","sequence":"additional","affiliation":[{"name":"School of Medicine Abadan University of Medical Sciences Abadan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4530-1080","authenticated-orcid":false,"given":"Sara","family":"Mobarak","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, School of Medicine Abadan University of Medical Sciences Abadan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5670-3595","authenticated-orcid":false,"given":"Maryam","family":"Adelipour","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, School of Medical Sciences Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9057-1506","authenticated-orcid":false,"given":"Maghsud","family":"Piri","sequence":"additional","affiliation":[{"name":"Vice Chancellor for Health Abadan University of Medical Sciences Abadan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1599-9374","authenticated-orcid":false,"given":"Maryam","family":"Seyedtabib","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology, School of Public Health Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1210-7222","authenticated-orcid":false,"given":"Sahar","family":"Golabi","sequence":"additional","affiliation":[{"name":"Department of Medical Physiology, School of Medicine Abadan University of Medical Sciences Abadan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","unstructured":"Michael ZietzNPT. 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