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Demographic trends from the recent coronavirus disease 2019 waves, which are believed to be driven by newer severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) variants, indicate that the aforementioned epidemiological barriers are being breached and a larger number of younger and healthy individuals are developing severe disease. The new SARS\u2010CoV\u20102 variants have key mutations that can induce significant changes in the virus\u2010host interactions. Recent studies report that, some of these mutations, singly or in a group, enhance key mechanisms, such as binding of the receptor\u2010binding domain (RBD) of the viral spike protein with the angiotensin\u2010converting enzyme 2 (ACE2) receptor in the host\u2010cells, increase the glycosylation of spike protein at the antigenic sites, and enhance the proteolytic cleavage of the spike protein, thus leading to improved host\u2010cell entry and the replication of the virus. The putative changes in the virus\u2013host interactions imparted by the mutations in the RBD sequence can potentially be the reason behind the breach of the observed epidemiological barriers. Susceptibility for contracting SARS\u2010CoV\u20102 infection and the disease outcomes are known to be influenced by host\u2010cell expressions of ACE2 and other proteases. The new variants can act more efficiently, and even with the lesser availability of the viral entry\u2010receptor and the associated proteases, can have more efficient host\u2010cell entry and greater replication resulting in high viral loads and prolonged viral shedding, widespread tissue\u2010injury, and severe inflammation leading to increased transmissibility and lethality. Furthermore, the accumulating evidence shows that multiple new variants have reduced neutralization by both, natural and vaccine\u2010acquired antibodies, indicating that repeated and vaccine breakthrough infections may arise as serious health concerns in the ongoing pandemic.<\/jats:p>","DOI":"10.1002\/jmv.27467","type":"journal-article","created":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T09:48:03Z","timestamp":1637660883000},"page":"1300-1314","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Emerging SARS\u2010CoV\u20102 variants can potentially break set epidemiological barriers in COVID\u201019"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1589-9568","authenticated-orcid":false,"given":"Ashutosh","family":"Kumar","sequence":"first","affiliation":[{"name":"Etiologically Elusive Disorders Research Network (EEDRN) New Delhi India"},{"name":"Department of Anatomy 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