{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T04:33:35Z","timestamp":1793075615162,"version":"4.5.0"},"reference-count":71,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T00:00:00Z","timestamp":1639440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T00:00:00Z","timestamp":1639440000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    To analyze the clinical presentation and outcomes of myocarditis after administration of the severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) messenger RNA (mRNA) vaccine. Nine case series and 15 case reports (74 patients) of myocarditis after administration of the BNT162b2 or mRNA\u20101273 vaccine were reviewed from PubMed, Scopus, Embase, and Web of Science. We analyzed clinical manifestations, diagnostic findings, and outcomes. In addition, we performed a pooled analysis and investigated risk factors leading to admission to the intensive care unit and recovery with conservative care. Most patients were male (94.6%), and the median age (range) was 17.6 (14\u201370) years. Patients who received the BNT162b2 (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200958, 78.4%) vaccine presented fewer systemic symptoms and left ventricular dysfunction than mRNA\u20101273 recipients. Although patients under 20 years experienced more fever and myalgia, they had better ejection fraction and less prominent myocardial inflammation in magnetic resonance imaging than older patients. The clinical course of all patients was favorable without mortality, and one\u2010third of patients resolved with conservative care alone. Risk factor analyses revealed that patients with gastrointestinal symptoms required intensive care (odds ratio: 20.3, 95% confidence interval 1.90\u2013217,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.013). The risk of fatality in myocarditis subjected to mRNA vaccination seems to be low. However,\u00a0patients with gastrointestinal symptoms received more intensive care, and a significant proportion of patients recovered with conservative management.\n                  <\/jats:p>","DOI":"10.1002\/jmv.27501","type":"journal-article","created":{"date-parts":[[2021,12,4]],"date-time":"2021-12-04T03:22:54Z","timestamp":1638588174000},"page":"1566-1580","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Clinical characteristics and prognostic factors of myocarditis associated with the mRNA COVID\u201019 vaccine"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0053-4470","authenticated-orcid":false,"given":"Wongi","family":"Woo","sequence":"first","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery Gangnam Severance Hospital, Yonsei University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0713-4461","authenticated-orcid":false,"given":"Ah Y.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Yonsei University College of Medicine Seoul Korea"},{"name":"Division of Pediatric Cardiology, Department of Pediatrics, Severance Cardiovascular Hospital Yonsei University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong K.","family":"Yon","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Seoul National University Hospital, Seoul National University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5632-5208","authenticated-orcid":false,"given":"Seung W.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Data Science Sejong University College of Software Convergence Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimin","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Jacob","sequence":"additional","affiliation":[{"name":"Parc Sanitari Sant Joan de Deu\/CIBERSAM, Fundacio Sant Joan de Deu, Sant Boi de Llobregat Universitat de Barcelona Barcelona Spain"},{"name":"Samsung Advanced Institute for Health Sciences &amp; Technology (SAIHST), Samsung Medical Center, Sungkyunkwan University Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai","family":"Koyanagi","sequence":"additional","affiliation":[{"name":"Parc Sanitari Sant Joan de Deu\/CIBERSAM, Fundacio Sant Joan de Deu, Sant Boi de Llobregat Universitat de Barcelona Barcelona Spain"},{"name":"Faculty of Medicine, University of Versailles Saint\u2010Quentin\u2010en\u2010Yvelines Montigny\u2010le\u2010Bretonneux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min S.","family":"Kim","sequence":"additional","affiliation":[{"name":"ICREA, Pg. Lluis Companys 23 Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duk H.","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery Gangnam Severance Hospital, Yonsei University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo W.","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Yonsei University College of Medicine Seoul Korea"},{"name":"Division of Pediatric Cardiology, Department of Pediatrics, Severance Cardiovascular Hospital Yonsei University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Y.","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Yonsei University College of Medicine Seoul Korea"},{"name":"Division of Pediatric Cardiology, Department of Pediatrics, Severance Cardiovascular Hospital Yonsei University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se Y.","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Yonsei University College of Medicine Seoul Korea"},{"name":"Division of Pediatric Cardiology, Department of Pediatrics, Severance Cardiovascular Hospital Yonsei University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy Y.","family":"Eun","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Yonsei University College of Medicine Seoul Korea"},{"name":"Division of Pediatric Cardiology, Department of Pediatrics, Severance Cardiovascular Hospital Yonsei University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sungsoo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery Gangnam Severance Hospital, Yonsei University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2326-1820","authenticated-orcid":false,"given":"Jae Il","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Yonsei University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee","family":"Smith","sequence":"additional","affiliation":[{"name":"Cambridge Centre for Health, Performance, and Wellbeing Anglia Ruskin University Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,14]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"COVID\u201019 Map \u2010 Johns Hopkins Coronavirus Resource Center. 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