{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:09:47Z","timestamp":1790766587353,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T00:00:00Z","timestamp":1641859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>As the latest identified novel severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) variant of concern (VOC), the influence of Omicron on our globe grows promptly. Compared with the last VOC (Delta variant), more mutations were identified, which may address the characteristics of Omicron. Considering these crucial mutations and their implications including an increase in transmissibility, COVID\u201019 severity, and reduction of efficacy of currently available diagnostics, vaccines, and therapeutics, Omicron has been classified as one of the VOC. Notably, 15 of these mutations reside in the receptor\u2010binding domain of spike glycoprotein, which may alter transmissibility, infectivity, neutralizing antibody escape, and vaccine breakthrough cases of COVID\u201019. Therefore, our present study characterizes the mutational hotspots of the Omicron variant in comparison with the Delta variant of SARS\u2010CoV\u20102. Furthermore, detailed information was analyzed to characterize the global perspective of Omicron, including transmission dynamic, effect on testing, and immunity, which shall promote the progress of the clinical application and basic research. Collectively, our data suggest that due to continuous variation in the spike glycoprotein sequences, the use of coronavirus\u2010specific attachment inhibitors may not be the current choice of therapy for emerging SARS\u2010CoV\u20102 VOCs. Hence, we need to proceed with a sense of urgency in this matter.<\/jats:p>","DOI":"10.1002\/jmv.27524","type":"journal-article","created":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T16:58:13Z","timestamp":1639501093000},"page":"1738-1744","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":260,"title":["Characterization of the novel SARS\u2010CoV\u20102 Omicron (B.1.1.529) variant of concern and its global perspective"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2856-4185","authenticated-orcid":false,"given":"Shailendra K.","family":"Saxena","sequence":"first","affiliation":[{"name":"Centre for Advanced Research (CFAR), Faculty of Medicine King George's Medical University (KGMU) Lucknow India"},{"name":"The World Society for Virology (WSV) Al\u2010Taif Saudi Arabia"},{"name":"The Indian Virological Society (IVS) New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swatantra","family":"Kumar","sequence":"additional","affiliation":[{"name":"Centre for Advanced Research (CFAR), Faculty of Medicine King George's Medical University (KGMU) Lucknow India"},{"name":"The World Society for Virology (WSV) Al\u2010Taif Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saniya","family":"Ansari","sequence":"additional","affiliation":[{"name":"Centre for Advanced Research (CFAR), Faculty of Medicine King George's Medical University (KGMU) Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janusz T.","family":"Paweska","sequence":"additional","affiliation":[{"name":"The World Society for Virology (WSV) Al\u2010Taif Saudi Arabia"},{"name":"Centre for Emerging Zoonotic and Parasitic Diseases, National Institute for Communicable Diseases of the National Health Laboratory Service, PB X4 Sandringham\u2010Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vimal K.","family":"Maurya","sequence":"additional","affiliation":[{"name":"Centre for Advanced Research (CFAR), Faculty of Medicine King George's Medical University (KGMU) Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil K.","family":"Tripathi","sequence":"additional","affiliation":[{"name":"Centre for Advanced Research (CFAR), Faculty of Medicine King George's Medical University (KGMU) Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed S.","family":"Abdel\u2010Moneim","sequence":"additional","affiliation":[{"name":"The World Society for Virology (WSV) Al\u2010Taif Saudi Arabia"},{"name":"Department of Microbiology, College of Medicine Taif University Al\u2010Taif Saudi Arabia"},{"name":"Department of Virology Beni\u2010Suef University Beni\u2010Suef Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.acx9738"},{"key":"e_1_2_9_3_1","unstructured":"World Health Organization. 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