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However, there is no review so far explaining the effect of the furin cleavage site of the spike protein on SARS\u2010CoV\u20102 replication and pathogenesis in the host and immune responses and vaccination. Therefore, here we specifically focused on genomic evolution and properties of the cleavage site of spike protein in the context of SARS\u2010CoV\u20102 followed by its effect on viral entry, replication, and pathogenesis. We also explored whether the spike protein furin cleavage site\u00a0affected the host immune responses and SARS\u2010CoV\u20102 vaccination. This review will help to provide novel insights into the effects of polybasic furin cleavage site on the current COVID\u201019 pandemic.<\/jats:p>","DOI":"10.1002\/jmv.27539","type":"journal-article","created":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T10:08:17Z","timestamp":1640167697000},"page":"1815-1820","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Roles of the polybasic furin cleavage site of spike protein in SARS\u2010CoV\u20102 replication, pathogenesis, and host immune responses and vaccination"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1487-5444","authenticated-orcid":false,"given":"Md. 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