{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T05:03:42Z","timestamp":1749618222544,"version":"3.37.3"},"reference-count":10,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T00:00:00Z","timestamp":1641859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Highlights<\/jats:title><jats:p>\n<jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Hundreds of clinical trials have been conducted on already available antiviral drugs or natural\/herbal substances to repurpose for the treatment of COVID\u201019, but with no conclusively consistent statistically significant positive results.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Remdesvir, for example, is facing a confusing situation, after the two major large multinational studies SOLIDARITY and DisCoVeRy concluded that there are no significant survival benefits.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In this viewpoint article, we claimed that the inconsistent time to initiate antiviral drugs during the course of COVID\u201012 studies is the major contributing factor for this dilemma. We explained that patients already on mechanical ventilation at the study baseline are considered from a biologically different population than other severity groups. We provided a simple meta\u2010meta\u2010analysis to show how excluding them from statistical analysis could affect the statistical significance and conclusions.<\/jats:p><\/jats:list-item><\/jats:list><\/jats:p>","DOI":"10.1002\/jmv.27565","type":"journal-article","created":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T09:05:32Z","timestamp":1640941532000},"page":"1757-1760","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Nonsignificant trends in COVID\u201019 trials: Is there a significance?"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6783-8268","authenticated-orcid":false,"given":"Mostafa","family":"Yakoot","sequence":"first","affiliation":[{"name":"Internal Medicine, Pediatrics and Translational Research Green Clinic and Research Center Alexandria Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,1,11]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2020.03.012"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.24875\/AIDSRev.200001261"},{"key":"e_1_2_4_4_1","first-page":"1015","article-title":"metaCOVID: an R\u2010Shiny application for living meta\u2010analyses of COVID\u201019 trials","volume":"173","author":"Evrenoglou T","year":"2021","journal-title":"medRxiv"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.16349"},{"issue":"21","key":"e_1_2_4_6_1","article-title":"Remdesivir plus standard of care versus standard of care alone for the treatment of patients admitted to hospital with COVID\u201019 (DisCoVeRy): a phase 3, randomised, controlled, open\u2010label trial [published online ahead of print, 2021 Sep 14]","volume":"1473","author":"Ader F","year":"2021","journal-title":"Lancet Infect Dis"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2023184"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2007764"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.7326\/M21-0653"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/ija.IJA_149_21"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31022-9"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.27565","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmv.27565","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.27565","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T21:25:51Z","timestamp":1692221151000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.27565"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,11]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1002\/jmv.27565"],"URL":"https:\/\/doi.org\/10.1002\/jmv.27565","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"type":"print","value":"0146-6615"},{"type":"electronic","value":"1096-9071"}],"subject":[],"published":{"date-parts":[[2022,1,11]]},"assertion":[{"value":"2021-10-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}