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Compared with the delta variant, the receptor\u2010binding domain (RBD) of omicron has an increased electrostatic surface potential, but a decreased affinity for the ACE\u20102 receptor. The N\u2010terminal domain (NTD) has both a decreased surface potential and a lower affinity for lipid rafts. The omicron variant is predicted to be less fusogenic and thus less pathogenic than delta, due to a geometric reorganization of the S1\u2010S2 cleavage site. Overall, these virological parameters suggest that omicron does not have a significant infectivity advantage over the delta variant. However, in omicron, neutralizing epitopes are greatly affected, suggesting that current vaccines will probably confer little protection against this variant. In conclusion, the puzzling mutational pattern of the omicron variant combines contradictory properties which may either decrease (virological properties) or increase (immunological escape\/facilitation) the transmission of this variant in the human population. This Janus\u2010like phenotype may explain some conflicting reports on the initial assessment of omicron and provide new insights about the molecular mechanisms controlling its dissemination and pathogenesis worldwide.<\/jats:p>","DOI":"10.1002\/jmv.27577","type":"journal-article","created":{"date-parts":[[2022,1,8]],"date-time":"2022-01-08T17:28:04Z","timestamp":1641662884000},"page":"2019-2025","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["The puzzling mutational landscape of the SARS\u20102\u2010variant Omicron"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8653-5521","authenticated-orcid":false,"given":"Jacques","family":"Fantini","sequence":"first","affiliation":[{"name":"Department of Biology Aix\u2010Marseille Universit\u00e9 Marseille France"},{"name":"INSERM UMR_S 1072 Marseille 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