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The etiological agent of this disease is the Omsk hemorrhagic fever virus (OHFV) which is closely related to the tick\u2010borne encephalitis virus (TBEV), and its range entirely lies within the TBEV area. OHFV belongs to the mammalian tick\u2010borne flaviviruses and the ecological group of arboviruses. The problem concerning the origin of OHFV remains unresolved to date. This study analyzed all nucleotide sequences of the OHFV genome obtained in the present study and available in GenBank, including the E gene fragment and the amino acid sequences of the surface glycoprotein encoded by it. The conclusions, based on the clusteron approach, suggest that OHFV originated directly from the TBEV of the Far Eastern subtype due to the host\u2010jump phenomenon, that is, through a rapid change from an arthropod host,<jats:italic>Ixodes persulcatus<\/jats:italic>, to a rodent,<jats:italic>O. zibethicus<\/jats:italic>. The muskrat was introduced to Western Siberia in the second half of the 1930s. The peculiarities of the biology and ecology of the muskrat in the new habitat became the reason for the TBEV cross\u2010species transmission. Calculations show that host\u2010jumping occurred between 1931 and 1947 and accompanied a cascade of adaptive amino acid substitutions in protein E. As a result, the virus changed its transmission to contact, alimentary, and airborne routes. Based on the data obtained, OHFV would be more correctly attributed to zoonotic viruses transmitted by rodents and, accordingly, to the ecological group of roboviruses.<\/jats:p>","DOI":"10.1002\/jmv.27581","type":"journal-article","created":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T06:19:59Z","timestamp":1641795599000},"page":"2510-2518","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Omsk hemorrhagic fever virus is a tick\u2010borne encephalitis virus adapted to muskrat through host\u2010jumping"],"prefix":"10.1002","volume":"94","author":[{"given":"Sergey\u00a0Y.","family":"Kovalev","sequence":"first","affiliation":[{"name":"Department of Biology, Institute of Natural Sciences and Mathematics Ural Federal University Yekaterinburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena A.","family":"Mazurina","sequence":"additional","affiliation":[{"name":"Department of Biology, Institute of Natural Sciences and Mathematics Ural Federal University Yekaterinburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,23]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"BusyginFF.Omsk Hemorragic Fever Omsk Research Institute of Natural Foci Infections.\u00a0Maksheeva; 2014 (in Russian)."},{"key":"e_1_2_9_3_1","first-page":"4","article-title":"Omsk hemorrhagic fever: current status of the problem","volume":"45","author":"Busygin FF","year":"2000","journal-title":"Vopr Virusol"},{"key":"e_1_2_9_4_1","first-page":"5","article-title":"The Omsk hemorrhagic fever: research results (1946\u20102013)","volume":"59","author":"Yastrebov VK","year":"2014","journal-title":"Vopr Virusol"},{"key":"e_1_2_9_5_1","first-page":"3","article-title":"Spring\u2010autumn fever in the Omsk oblast","volume":"13","author":"Akhrem\u2010Akhremovich RM","year":"1948","journal-title":"Trud\u00a0Omsk\u00a0Med\u00a0Inst"},{"key":"e_1_2_9_6_1","unstructured":"LvovDK KlimenkoSM GaidamovichSY. 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