{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T11:55:27Z","timestamp":1783338927390,"version":"3.54.6"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,1,21]],"date-time":"2022-01-21T00:00:00Z","timestamp":1642723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To expand our understanding of the role of angiotensin II (ANGII) in coronavirus infectious disease 2019 (COVID\u201019), we conducted an international, multicenter registry study to assess the use of ANGII in patients with COVID\u201019 compared to patients not receiving ANGII. Critically ill adult patients who were diagnosed with COVID\u201019 and received ANGII were matched with COVID\u201019 patients not receiving ANGII according to age, respiratory support, history of hypertension, use of angiotensin\u2010converting enzyme inhibitors and\/or ANGII receptor blocker, and date of admission. All outcomes were exploratory in nature and included improvement in oxygenation, duration of organ support, and mortality. In one year, 132 patients were included (65 in the ANGII group and 67 in the control group), and patients were comparable in baseline characteristics. During the first 12\u2009h of infusion, patients in the ANGII had a faster decrease in FiO<jats:sub>2<\/jats:sub>\u00a0and maintained similar mean arterial pressure levels. Hospital mortality was not statistically significantly different between the groups (53.8% vs. 40.3%;<jats:italic>p<\/jats:italic>\u2009=\u20090.226). Within the limitations of such a study design, our findings confirm previous observations of a potentially positive effect of ANGII on blood pressure and FiO<jats:sub>2<\/jats:sub>but no effect on patient\u2010centered outcomes.<\/jats:p>","DOI":"10.1002\/jmv.27592","type":"journal-article","created":{"date-parts":[[2022,1,14]],"date-time":"2022-01-14T11:44:13Z","timestamp":1642160653000},"page":"2079-2088","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Angiotensin II infusion in COVID\u201019: An international, multicenter, registry\u2010based study"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1520-9387","authenticated-orcid":false,"given":"Ary","family":"Serpa Neto","sequence":"first","affiliation":[{"name":"Australian and New Zealand Intensive Care Research Centre Monash University Melbourne Australia"},{"name":"Department of Critical Care Medicine Hospital Israelita Albert Einstein Sao Paulo Brazil"},{"name":"Department of Critical Care University of Melbourne Melbourne Australia"},{"name":"Data Analytics Research and Evaluation (DARE) Centre Austin Hospital Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Landoni","sequence":"additional","affiliation":[{"name":"Department of Intensive Care and Anesthesiology IRCCS San Raffaele Scientific Institute Milan Italy"},{"name":"Vita\u2010Salute San Raffaele University Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlies","family":"Ostermann","sequence":"additional","affiliation":[{"name":"Department of Critical Care Guys &amp; St Thomas' Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuttha","family":"Lumlertgul","sequence":"additional","affiliation":[{"name":"Department of Critical Care Guys &amp; St Thomas' Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lui","family":"Forni","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Royal Surrey County Hospital NHS Foundation Trust Surrey UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Alvarez\u2010Belon","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Royal Surrey County Hospital NHS Foundation Trust Surrey UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"Trapani","sequence":"additional","affiliation":[{"name":"Australian and New Zealand Intensive Care Research Centre Monash University Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia V.","family":"Alliegro","sequence":"additional","affiliation":[{"name":"Australian and New Zealand Intensive Care Research Centre Monash University Melbourne 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