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One hundred and ninety\u00a0COVID\u201019 patients (juveniles, adults) and 43 volunteers as healthy controls were enrolled in our study. Flow cytometric analysis was performed using a 10\u2010color monoclonal antibody panel from peripheral blood samples. In adult patients, CD39<jats:sup>+<\/jats:sup> Tregs increased with disease severity. In contrast, CD39<jats:sup>+<\/jats:sup> Tregs were decreased in juvenile patients in an age\u2010dependent manner. Overall, our study reveals an interesting profile of CD39\u2010expressing Tregs in adult and juvenile cases of COVID\u201019. Our results provide a better understanding of the possible role of Tregs in the mechanism of immune response in COVID\u201019 cases.<\/jats:p>","DOI":"10.1002\/jmv.27593","type":"journal-article","created":{"date-parts":[[2022,1,15]],"date-time":"2022-01-15T04:55:15Z","timestamp":1642222515000},"page":"2089-2101","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Assessment of CD39 expression in regulatory T\u2010cell subsets by disease severity in adult and juvenile COVID\u201019 cases"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8850-0269","authenticated-orcid":false,"given":"Abdurrahman","family":"Simsek","sequence":"first","affiliation":[{"name":"Department of Immunology, Faculty of Medicine Bursa Uluda\u011f University Bursa Turkey"},{"name":"Department of Immunology, Health Science Institute Bursa Uludag University Bursa Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5334-7911","authenticated-orcid":false,"given":"Muhammed A.","family":"Kizmaz","sequence":"additional","affiliation":[{"name":"Department of Immunology, Faculty of Medicine Bursa Uluda\u011f University Bursa Turkey"},{"name":"Department of Immunology, Health Science Institute Bursa Uludag University Bursa Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5640-9196","authenticated-orcid":false,"given":"Eren","family":"Cagan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Infectious Diseases Bursa Yuksek Ihtisas Training and Research Hospital, University of Health Sciences Bursa Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7288-3250","authenticated-orcid":false,"given":"Fatma","family":"Dombaz","sequence":"additional","affiliation":[{"name":"Department of Immunology, Faculty of Medicine Bursa Uluda\u011f University Bursa Turkey"},{"name":"Department of Immunology, Health Science Institute Bursa Uludag University Bursa Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5956-8755","authenticated-orcid":false,"given":"Gulcin","family":"Tezcan","sequence":"additional","affiliation":[{"name":"Department of Fundamental Science, Faculty of Dentistry Bursa Uluda\u011f University Bursa Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8856-7356","authenticated-orcid":false,"given":"Ali","family":"Asan","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Bursa Yuksek Ihtisas Training and Research Hospital, University of Health Sciences Bursa Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7585-7971","authenticated-orcid":false,"given":"H. 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