{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:24:02Z","timestamp":1790871842213,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T00:00:00Z","timestamp":1643328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Remdesivir is a broad\u2010spectrum antiviral agent able to inhibit the RNA polymerase of SARS\u2010CoV\u20102. At present, studies focusing on the effect of remdesivir on viral load (VL) are few and with contrasting results. Aim of the present study was to evaluate the effect of remdesivir on SARS\u2010CoV\u20102 VL from nasopharyngeal swabs (cycle threshold criterion) in a sample of patients treated with the drug, compared with patients who did not receive the antiviral treatment.\u00a0This retrospective analysis evaluated patients with (1) real\u2010time polymerase chain reaction (RT\u2010PCR) confirmed COVID\u201019 diagnosis and (2) availability of at least two positive nasopharyngeal swabs analysed with the same analytic platform (ORF target gene, Ingenius ELITe, ELITechGroup, Puteaux, France). Upper respiratory specimens from nasopharyngeal swabs were collected at admission (T0) and 7\u201314 days after treatment, upon clinical decision. A total of 27 patients treated with remdesivir (Group A) met the inclusion criteria and were compared with 18 patients (Group B) treated with standard care, matched for baseline clinical characteristics.\u00a0At baseline, both remdesivir\u2010treated and nontreated patients showed comparable VLs (21.73\u2009\u00b1\u20096.81 vs. 19.27\u2009\u00b1\u20095.24, <jats:italic>p<\/jats:italic>\u2009=\u20090.348). At the second swab, remdesivir\u2010treated patients showed a steeper VL reduction with respect to controls (34.28\u2009\u00b1\u20097.73 vs. 27.22\u2009\u00b1\u20093.92; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Longitudinal linear model estimated a mean decrease in cycle threshold equal to 0.61 (SE: 0.09) per day in remdesivir\u2010treated versus 0.33 (SE: 0.10) per day in remdesivir nontreated patients (<jats:italic>p<\/jats:italic> for heterogeneity\u2009=\u20090.045).\u00a0The present study shows that the administration of remdesivir in hospitalized COVID\u201019 patients significantly reduces the VL on nasopharyngeal swabs.<\/jats:p>","DOI":"10.1002\/jmv.27598","type":"journal-article","created":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T07:58:18Z","timestamp":1642579098000},"page":"2284-2289","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Remdesivir significantly reduces SARS\u2010CoV\u20102 viral load on nasopharyngeal swabs in hospitalized patients with COVID\u201019: A retrospective case\u2013control study"],"prefix":"10.1002","volume":"94","author":[{"given":"Annalucia","family":"Biancofiore","sequence":"first","affiliation":[{"name":"Unit of Pharmacy, Department of Pharmaceuticals IRCCS Casa Sollievo della Sofferenza San Giovanni Rotondo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3932-3803","authenticated-orcid":false,"given":"Antonio","family":"Mirijello","sequence":"additional","affiliation":[{"name":"Unit of Internal Medicine, Department of Medical Sciences IRCCS Casa Sollievo della Sofferenza San Giovanni Rotondo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria A.","family":"Puteo","sequence":"additional","affiliation":[{"name":"Unit of Pharmacy, Department of Pharmaceuticals IRCCS Casa Sollievo della Sofferenza San Giovanni Rotondo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria P.","family":"Di Viesti","sequence":"additional","affiliation":[{"name":"Unit of 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