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These vaccines have shown great efficacy and safety profile. One side effect that has been widely reported is post\u2010COVID\u201019 vaccination lymphadenopathy. Due to the mimicry of the lymphadenopathy for metastases in some oncologic patients, there have been reports of patients who underwent biopsies that showed pathologic confirmation of benign reactive lymphadenopathy secondary to the COVID\u201019 vaccine. Therefore, understanding the incidence of lymphadenopathy post\u2010COVID\u201019 vaccinations will help guide radiologists and oncologists in their management of patients, both present oncologic patients, and patients with concerns over their newly presenting lymphadenopathy. A systematic literature search was performed using several databases to identify relevant studies that reported lymphadenopathy post\u2010COVID\u201019 vaccination. Our results revealed that several cases have been detected in patients undergoing follow\u2010up fluorodeoxyglucose (FDG)\u2010positron emission tomography\u2010computerized tomography scans where lymph nodes ipsilateral to the vaccine injection site show increased uptake of FDG. Thus, knowledge of the incidence of lymphadenopathy may help avoid unnecessary biopsies, interventions, and changes in management for patients, especially oncologic patients who are at risk for malignancies.<\/jats:p>","DOI":"10.1002\/jmv.27599","type":"journal-article","created":{"date-parts":[[2022,1,21]],"date-time":"2022-01-21T07:02:56Z","timestamp":1642748576000},"page":"1833-1845","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Lymphadenopathy post\u2010COVID\u201019 vaccination with increased FDG uptake may be falsely attributed to oncological disorders: A systematic review"],"prefix":"10.1002","volume":"94","author":[{"given":"Khalifa","family":"Bshesh","sequence":"first","affiliation":[{"name":"Division of Medical Education, Weill Cornell Medicine\u2010Qatar Qatar Foundation, Education City Doha 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