{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T05:58:01Z","timestamp":1781848681975,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T00:00:00Z","timestamp":1643932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The novel Severe acute respiratory syndrome coronavirus\u20102 (SARS\u2010CoV\u20102) variant, Omicron (PANGO lineage B.1.1.529) is being reported from all around the world. The WHO has categorized Omicron as a Variant of Concern (VOC) considering its higher transmissibility and infectivity, vaccine breakthrough cases. As of January\u00a06, 2022, Omicron has been reported in at least 149 countries. Therefore, this study was planned to investigate the transmission dynamics and mutational prevalence of the novel SARS\u2010CoV\u20102 Omicron variant. The transmission dynamics and Omicron SARS\u2010CoV\u20102 divergence was studied using GISAID and Nextstrain which provides information about the genetic sequences, epidemiological, geographical, and species\u2010specific data of human, avian, and animal viruses. Further, the mutation prevalence in spike glycoprotein of Omicron was studied, and the frequency of the crucial mutations was compared with the other prevalent VOCs. The transmission dynamics suggest that the Omicron was first identified in South Africa and then it was reported in the United Kingdom followed by the United States and Australia. Further, our phylogenetic analysis suggests that Omicron (BA.1) was clustered distinctly from the other VOCs. In the Spike glycoprotein, the Omicron (B.1.1.529) demonstrates critical 32 amino acid changes. This study may help us to understand mutational hotspots, transmission dynamics, phylogenetic divergence, effect on testing and immunity, which shall promote the progress of the clinical application and basic research.<\/jats:p>","DOI":"10.1002\/jmv.27611","type":"journal-article","created":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T13:48:37Z","timestamp":1642686517000},"page":"2160-2166","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Transmission dynamics and mutational prevalence of the novel Severe acute respiratory syndrome coronavirus\u20102 Omicron Variant of Concern"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2856-4185","authenticated-orcid":false,"given":"Shailendra K.","family":"Saxena","sequence":"first","affiliation":[{"name":"Centre for Advanced Research (CFAR), Faculty of Medicine King George's Medical University (KGMU)  Lucknow India"},{"name":"World Society for Virology (WSV)  Al\u2010Taif Saudi Arabia"},{"name":"The Indian Virological Society (IVS)  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swatantra","family":"Kumar","sequence":"additional","affiliation":[{"name":"Centre for Advanced Research (CFAR), Faculty of Medicine King George's Medical University (KGMU)  Lucknow India"},{"name":"World Society for Virology (WSV)  Al\u2010Taif Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saniya","family":"Ansari","sequence":"additional","affiliation":[{"name":"Centre for Advanced Research (CFAR), Faculty of Medicine King George's Medical University (KGMU)  Lucknow India"},{"name":"World Society for Virology (WSV)  Al\u2010Taif Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janusz T.","family":"Paweska","sequence":"additional","affiliation":[{"name":"World Society for Virology (WSV)  Al\u2010Taif Saudi Arabia"},{"name":"Centre for Emerging Zoonotic and Parasitic Diseases National Institute for Communicable Diseases of the National Health Laboratory Service, PB X4  Sandringham\u2010Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vimal K.","family":"Maurya","sequence":"additional","affiliation":[{"name":"Centre for Advanced Research (CFAR), Faculty of Medicine King George's Medical University (KGMU)  Lucknow India"},{"name":"World Society for Virology (WSV)  Al\u2010Taif Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil K.","family":"Tripathi","sequence":"additional","affiliation":[{"name":"Centre for Advanced Research (CFAR), Faculty of Medicine King George's Medical University (KGMU)  Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed S.","family":"Abdel\u2010Moneim","sequence":"additional","affiliation":[{"name":"Department of Microbiology, College of Medicine Taif University  Al\u2010Taif Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0262-4079(21)02140-0"},{"key":"e_1_2_9_3_1","first-page":"1","article-title":"Characterization of the novel SARS\u2010CoV\u20102 Omicron (B.1.1.529) Variant of Concern and its global perspective","author":"Saxena SK","year":"2022","journal-title":"J Med Virol"},{"key":"e_1_2_9_4_1","unstructured":"World Health Organization.Naming SARS\u2010CoV\u20102 Variants. 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