{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,4,28]],"date-time":"2024-04-28T05:54:12Z","timestamp":1714283652773},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T00:00:00Z","timestamp":1643932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006507","name":"Funda\u00e7\u00e3o Oswaldo Cruz","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006507","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) infection can generate a systemic inflammatory response, characterized by a cytokine storm and associated with an exaggerated release of proinflammatory cytokines, including tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1), interleukin\u20106 (IL\u20106), and IL\u201017, all of which can affect the liver. Here, we aimed to evaluate the cytokine profiles of patients suffering from coronavirus disease (COVID)\u201019 and\/or hepatitis. We subjected 87 patients to serology and\/or polymerase chain reaction analysis for the hepatitis C virus. They were also tested for TNF\u2010\u03b1, IL\u20106, and IL\u201017 using commercial immunoassay kits. The test results of the COVID\u201019\/hepatitis C patients (<jats:italic>n<\/jats:italic>\u2009=\u20098) were compared with that of the negative controls (<jats:italic>n<\/jats:italic>\u2009=\u200928), hepatitis C patients (<jats:italic>n<\/jats:italic>\u2009=\u200929), and COVID\u201019 patients (<jats:italic>n<\/jats:italic>\u2009=\u200922). All COVID\u201019 patients (mono\u2010 and coinfected) expressed high levels of cytokines. The COVID\u201019\/hepatitis patients exhibited higher levels of IL\u20106 (6.33\u2009\u00b1\u20093.9\u2009pg\/ml)\u00a0and IL\u201017 (102.23\u2009\u00b1\u20092.7\u2009pg\/ml); however, TNF\u2010\u03b1 values were lower (68.08\u2009\u00b1\u200915.88\u2009pg\/ml), as compared with that of the hepatitis patients (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and lower than that of the COVID\u201019 patients and exceptionally for TNF\u2010\u03b1 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). These data highlight the importance of monitoring patients with hepatitis and COVID\u201019.<\/jats:p>","DOI":"10.1002\/jmv.27614","type":"journal-article","created":{"date-parts":[[2022,1,22]],"date-time":"2022-01-22T09:33:43Z","timestamp":1642844023000},"page":"2296-2301","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Immunological and virological aspects of severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) and hepatitis C virus"],"prefix":"10.1002","volume":"94","author":[{"given":"Fabiola Justina Fumero","family":"Le\u00f3n","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Virology, Oswaldo Cruz Institute Oswaldo Cruz Foundation  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas Lima","family":"da Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Viral Hepatitis, Oswaldo Cruz Institute Oswaldo Cruz Foundation  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alanna Calheiros","family":"Santos","sequence":"additional","affiliation":[{"name":"Laboratory of Viral Hepatitis, Oswaldo Cruz Institute Oswaldo Cruz Foundation  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Duarte da Costa","sequence":"additional","affiliation":[{"name":"Laboratory of Viral Hepatitis, Oswaldo Cruz Institute Oswaldo Cruz Foundation  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana Cust\u00f3dio","family":"Miguel","sequence":"additional","affiliation":[{"name":"Laboratory of Viral Hepatitis, Oswaldo Cruz Institute Oswaldo Cruz Foundation  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia Trece","family":"Marques","sequence":"additional","affiliation":[{"name":"Laboratory of Viral Hepatitis, Oswaldo Cruz Institute Oswaldo Cruz Foundation  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giselle Prado","family":"Nascimento","sequence":"additional","affiliation":[{"name":"Laboratory of Viral Hepatitis, Oswaldo Cruz Institute Oswaldo Cruz Foundation  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisangela","family":"Ferreira da Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Viral Hepatitis, Oswaldo Cruz Institute Oswaldo Cruz Foundation  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lia Laura","family":"Lewis\u2010Ximenez","sequence":"additional","affiliation":[{"name":"Laboratory of Viral Hepatitis, Oswaldo Cruz Institute Oswaldo Cruz Foundation  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Livia Melo","family":"Villar","sequence":"additional","affiliation":[{"name":"Laboratory of Viral Hepatitis, Oswaldo Cruz Institute Oswaldo Cruz Foundation  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa Salete","family":"de Paula","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Virology, Oswaldo Cruz Institute Oswaldo Cruz Foundation  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,2,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2002032"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m606"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30079-5"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000001459"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.3.47"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-021-00426-4"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v12.i8.413"},{"key":"e_1_2_10_9_1","unstructured":"CDC (Centers for Disease Control and Prevention). Dispon\u00edvel em.\u00a0junho 2021.\u00a0https:\/\/www.cdc.gov\/coronavirus\/2019-ncov\/lab\/rt-pcr-panel-primerprobes.html\/\u00a0"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2020.25.3.2000045"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.1040752"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640620924157"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.49713"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2020.1770129"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2016.0044"},{"key":"e_1_2_10_16_1","article-title":"Saliva viral load is a dynamic unifying correlate of COVID\u201019 severity and mortality","author":"Silva J","year":"2021","journal-title":"medRxiv"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.3877"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v27.i42.7362"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2020.05.002"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpha.2020.03.001"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-0328-z"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753466620926800"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.27614","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmv.27614","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.27614","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T21:28:28Z","timestamp":1692221308000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.27614"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,4]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1002\/jmv.27614"],"URL":"https:\/\/doi.org\/10.1002\/jmv.27614","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,4]]},"assertion":[{"value":"2021-11-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}