{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:16:01Z","timestamp":1740104161844,"version":"3.37.3"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,2,14]],"date-time":"2022-02-14T00:00:00Z","timestamp":1644796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sinovac is an inactive vaccine produced against Coronavirus Disease 2019 (COVID\u201019) for almost a year. No sufficient information is available concerning pro\u2010vaccine immunogenicity. We investigated the efficacy of antibody response following vaccination of SARS\u2010CoV\u20102\u2010infected and noninfected healthcare workers by a two\u2010dose inactive vaccine against COVID\u201019. The immunogenicity acquired on the\u00a027th day and 42nd day after the first dose of vaccine (corresponding to Day\u00a014\u00a0after the second dose) were compared by the demographics, immunosuppression, comorbidities, postvaccination reaction, and IgG levels of 120 subjects. The overall rate of second postvaccine seropositivity was 97.5% (<jats:italic>n<\/jats:italic>\u2009=\u2009117) of all individuals, and 44 of these were seropositive after the first dose. The percentage of having a previous COVID\u201019 (59.1%) among seropositive individuals before 2nd vaccination was significantly higher than those of seropositive individuals (10.96%) after second vaccination (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). In our study, 35 healthcare workers stated that they had previously had a COVID\u201019 infection. Anti\u2010SARS\u2010CoV\u20102 antibody responses in people infected with SARS\u2010CoV\u20102 follow a classical pattern, with a rapid increase within the first 3 weeks after the appearance of symptoms. Although the titers decreased thereafter, the ability to detect anti\u2010SARS\u2010CoV\u20102 IgG antibodies supports the view that the majority of subjects previously screened as positive for virus remain intact with confirmed neutralizing activity for up to 6 months.<\/jats:p>","DOI":"10.1002\/jmv.27649","type":"journal-article","created":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T02:29:30Z","timestamp":1644200970000},"page":"2431-2437","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Efficacy of antibody response following the vaccination of SARS\u2010CoV\u20102 infected and noninfected healthcare workers by two\u2010dose inactive vaccine against COVID\u201019"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1052-5911","authenticated-orcid":false,"given":"Bagnu","family":"Dundar","sequence":"first","affiliation":[{"name":"Department of Medical Biochemistry Istanbul Atlas University Faculty of Medicine  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0683-7018","authenticated-orcid":false,"given":"Kadriye","family":"Karahangil","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology Istanbul Atlas University Faculty of Medicine  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9412-6568","authenticated-orcid":false,"given":"Cagri Serdar","family":"Elgormus","sequence":"additional","affiliation":[{"name":"First and Emergency Aid Program, Istanbul Atlas University Vocational School  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3158-2165","authenticated-orcid":false,"given":"Hatice Nur Halipci","family":"Topsakal","sequence":"additional","affiliation":[{"name":"Disinfection, Sterilization and Antisepsis Program, Istanbul Atlas University Vocational School  Istanbul Turkey"},{"name":"College of Biomedical Engineering, Ohio State University Columbus USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,2,14]]},"reference":[{"issue":"5","key":"e_1_2_10_2_1","first-page":"1957","article-title":"Post\u2010vaccination (COVID\u201019) impacts in healthcare personnel","volume":"34","author":"Shahid S","year":"2021","journal-title":"Pak J Pharm Sci"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/14760584.2022.2012457"},{"key":"e_1_2_10_4_1","unstructured":"World Health Organization (WHO).8 Vaccines Approved for Use by WHO. 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