{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:32:08Z","timestamp":1792114328378,"version":"4.4.0"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T00:00:00Z","timestamp":1646265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aims to analyze the difference in clinical features and prognosis of severe adenovirus pneumonia (SAP) in children of different ages and analyze the risk factors for poor prognosis in children with SAP. A retrospective observational study was performed to describe the clinical features and analyze the risk factors for death and postinfectious bronchiolitis obliterans (PIBO) in 303 children hospitalized with SAP from January 2015 through to January 2020. The participants were divided into four age groups: &lt;6 months (<jats:italic>n<\/jats:italic>\u2009=\u200925, 8.3%); 6\u201312 months (<jats:italic>n<\/jats:italic>\u2009=\u200998, 32.3%); 12\u201336 months (<jats:italic>n<\/jats:italic>\u2009=\u2009118, 38.9%); and &gt;36 months (<jats:italic>n<\/jats:italic>\u2009=\u200962, 20.5%). Fever rate, peak, and duration were the lowest in the &lt;6 months group, while no significant difference was found among other age groups. Serum levels of lactate dehydrogenase\u00a0and a load of adenovirus were the lowest in the &lt;6 months group, and the highest in the 6\u201312\u00a0and 12\u201336 months groups, respectively. A total of 80.9% of patients recovered, 3.3% of patients died, and 15.8% of patients were diagnosed with PIBO. The mortality rate showed no significance between age groups. The &gt;36 months group had the highest recovery rate and the lowest incidence of PIBO, while the 6\u201312 months group had the lowest recovery rate and the highest incidence of PIBO. Independent risk factors for PIBO among all participants from the four groups were invasive mechanical ventilation, administration of intravenous steroids, duration of fever, and male gender. Independent risk factors for death among all participants from the four groups were hypercapnia, low albumin levels, and invasive mechanical ventilation. Risk factor analysis of different ages was not possible due to the limited sample size. The morbidity, clinical features, and prognosis of SAP are affected by children's ages. Pediatric patients with a longer duration of fever, hypercapnia, low serum albumin levels, invasive mechanical ventilation, and intravenous steroids use are more likely to develop a poor prognosis in SAP, especially if the patient is male.<\/jats:p>","DOI":"10.1002\/jmv.27680","type":"journal-article","created":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T22:13:36Z","timestamp":1645827216000},"page":"3303-3311","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["The difference in clinical features and prognosis of severe adenoviral pneumonia in children of different ages"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2157-388X","authenticated-orcid":false,"given":"Xia","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pediatrics Second Affiliated Hospital of Army Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangsheng","family":"Tan","sequence":"additional","affiliation":[{"name":"The First Hospital Affiliated to Army Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qubei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of the Respiratory Medicine Children's Hospital of Chongqing Medical University  Chongqing China"},{"name":"National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders Children's Hospital of Chongqing Medical University  Chongqing China"},{"name":"Chongqing Key Laboratory of Pediatrics  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0205795"},{"issue":"4","key":"e_1_2_9_3_1","first-page":"650","article-title":"Causative agents of severe community acquired viral pneumonia among children in eastern Thailand","volume":"46","author":"Pratheepamornkull T","year":"2015","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-018-1037-0"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25333"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/4878635"},{"key":"e_1_2_9_7_1","article-title":"Seroprevalence of neutralizing antibodies to human adenovirus in healthy people and identification of neutralizing epitopes of human adenovirus type 3 by monoclonal antibody","author":"Sheng H","year":"2013","journal-title":"Southern Med\u00a0Univ"},{"key":"e_1_2_9_8_1","first-page":"1","article-title":"Seroprevalence of neutralizing antibodies against six human adenovirus types indicates the low level of herd immunity in young children from Guangzhou, China","volume":"9","author":"Tian X","year":"2020","journal-title":"Virol Sin"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2014.3085"},{"key":"e_1_2_9_10_1","unstructured":"National Health Commission of the People's Republic of China State of Administration of Traditional Chinese Medicine. 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