{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:47:17Z","timestamp":1790833637040,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T00:00:00Z","timestamp":1646697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Coronavirus disease 2019 (COVID\u201019) is spreading worldwide; there is a need to address its sequelae known as Long COVID. This study evaluated postvaccination changes in symptoms and antibody titers in patients with Long COVID. Patients visiting the outpatient department specializing in Long COVID at our hospital were enrolled. Changes in symptoms were evaluated before and 14\u201321 days after first vaccination. Antibody titers were measured using ARCHITECT SARS\u2010CoV\u20102 IgG II Quant at the same time. This study included 42 patients (median age: 45 years; 17 [40.5%] men). Median pre\u2010 and postvaccination antibody titers were 456\u00a0and 28,963\u2009AU\/ml, respectively. Postvaccination symptoms (fatigue, joint pain, and taste and olfactory abnormalities) were relieved, worsened, and unchanged in 7 (16.7%), 9 (21.4%), and 26 (61.9%) patients, respectively. Ratios of pre\u2010 and postvaccination antibody titers were 53, 40, and 174 in the unchanged, relief, and worsened groups, respectively. The worsened group had the significantly highest antibody titer ratio (<jats:italic>p<\/jats:italic>\u2009=\u20090.02). The higher increased rate of the antibody titer in the worsened group than in the nonworsened group suggests an excessive immune response to vaccination associated with worsening of sequelae. Although patients with Long COVID should be vaccinated, additional concerns should be addressed.<\/jats:p>","DOI":"10.1002\/jmv.27689","type":"journal-article","created":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T23:18:20Z","timestamp":1646263100000},"page":"3416-3420","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Relationship between changes in symptoms and antibody titers after a single vaccination in patients with Long COVID"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8517-3941","authenticated-orcid":false,"given":"Tomoya","family":"Tsuchida","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, St. Marianna University School of Medicine Division of General Internal Medicine  Kawasaki Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Hirose","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, St. Marianna University School of Medicine Division of General Internal Medicine  Kawasaki Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, St. Marianna University School of Medicine Division of General Internal Medicine  Kawasaki Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Kunishima","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases St. Marianna University School of Medicine  Kawasaki Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehito","family":"Otsubo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological and General Surgery St. Marianna University School of Medicine  Kawasaki Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahide","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, St. Marianna University School of Medicine Division of General Internal Medicine  Kawasaki Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,8]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"Ministry of Health Labour and Welfare. Domestic outbreaks etc. Accessed December 11 2021.https:\/\/www.mhlw.go.jp\/stf\/covid-19\/kokunainohasseijoukyou.html"},{"key":"e_1_2_9_3_1","unstructured":"Prime Minister's Office of Japan. About the novel coronavirus vaccines in Japan. Accessed December 10 2021.https:\/\/www.kantei.go.jp\/jp\/headline\/kansensho\/vaccine.html"},{"key":"e_1_2_9_4_1","unstructured":"World Health Organization. A clinical case definition of post COVID\u201019 condition by a Delphi consensus. October 6 2021. 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